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Application of icaritin in preparing medicament for preventing and treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and icariin, which is applied in the fields of cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve the problem that the therapeutic effect of coronary heart disease has not been reported yet.

Inactive Publication Date: 2010-02-03
周亚伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Icaritin has the effect of anti-Aβ peptide-induced apoptosis of rat primary cultured nerve cells (literature [2]: Zhang Xiangnan, Wang Huanhuan, Wang Zhiqiang et al., Icaritin anti-Aβ peptide-induced apoptosis of rat primary cultured nerve cells The role of Zhejiang University, 2007, 36 (3): 224-226), but its therapeutic effect on coronary heart disease has not been reported

Method used

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  • Application of icaritin in preparing medicament for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of icaritin in preparing medicament for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of icaritin in preparing medicament for preventing and treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Effects of Icaritin and Icariin on Experimental Myocardial Infarction in Rats Induced by Coronary Artery Ligation

[0019] 144 Wistar rats were randomly divided into 9 groups, 16 in each group: sham operation group, model group, positive drug group (diltiazem hydrochloride 6mg / kg), low-dose icariin group (8mg / kg) , icariin medium-dose group (15mg / kg), icariin high-dose group (30mg / kg), icariin low-dose group (8mg / kg), icariin medium-dose group (15mg / kg) kg), high-dose icariin group (30mg / kg). Coronary artery ligation was used to reproduce the animal model of myocardial infarction, and its effects on electrocardiogram, myocardial infarction area and myocardial enzymes were investigated at 30 minutes after ligation, 1 h, 2 h, 3 h, 4 h, and 5 h after administration. The results are shown in Table 1-3.

[0020] Table 1 Effects of icariin and icariin on the absolute value of T wave changes in rats with experimental myocardial infarction induced by coronary arter...

Embodiment 2

[0036] Example 2: Effect of icariin on cerebral infarction in rats caused by middle cerebral artery ligation.

[0037] 96 Wistar rats were randomly divided into 6 groups, 16 in each group: sham operation group, model group, positive drug group (nimodipine 30mg / kg), icariin small dose group (8mg / kg ), middle dose group of icariin (15mg / kg), high dose group of icariin (30mg / kg). The animal model of local cerebral infarction was reproduced by ligating the middle cerebral artery in rats, and its effect on local cerebral ischemia and infarction was observed, and its effect on the size of cerebral infarction was investigated. The results are shown in Table 4.

[0038] Table 4 The effect of icaridin on the percentage of cerebral infarction area in the whole brain area caused by middle cerebral artery ligation in rats (x ± s)

[0039]

[0040] Compared with the model group, ** P*** P<0.001

[0041] It can be seen from Table 4 that after unilateral middle cerebral artery ligation,...

Embodiment 3

[0042] Example 3: The effect of icariin on the percentage of cerebral infarction area to total brain area in rat middle cerebral artery ischemia-reperfusion model.

[0043] 96 Wistar rats were randomly divided into 6 groups, 16 in each group: sham operation group, model group, positive drug group (nimodipine 30mg / kg), icariin small dose group (8mg / kg ), middle dose group of icariin (15mg / kg), high dose group of icariin (30mg / kg). The common carotid artery was inserted into the middle cerebral artery to block the middle cerebral artery of the rat, and then reperfused after 1 hour of ischemia, resulting in an ischemia-reperfusion injury model. Investigate its influence on infarction caused by reperfusion after regional cerebral ischemia, and examine its influence on cerebral infarction size. The results are shown in Table 5.

[0044] Table 5 The effect of icariin on the percentage of cerebral infarction area in rat middle cerebral artery ischemia-reperfusion model in the whole...

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Abstract

The invention relates to application of icaritin in preparation of a medicament for preventing and treating cardiovascular and cerebrovascular diseases. Tests prove that the icaritin has the effect ofsignificantly preventing and treating the cardiovascular and cerebrovascular diseases, particularly has the effect of significantly preventing and treating coronary heart disease. The invention alsoprovides a medicinal preparation of the icaritin for preventing and treating the coronary heart disease.

Description

technical field [0001] The invention relates to the application of a compound in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases, in particular to the application of icariin in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are characterized by acute onset, high mortality, and high disability rate. Cardiovascular and cerebrovascular diseases have become the number one killer endangering people's health. According to statistics from the Ministry of Health, there are about 70 million patients with stroke and its sequelae in my country, 60 million patients with coronary heart disease, and 57% of middle-aged and elderly people over the age of 40 suffer from various degrees of cardiovascular and cerebrovascular diseases. With the aging of the population, the incidence of cardiovascular and cerebrovascular di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10
Inventor 周亚伟
Owner 周亚伟