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Micronomicin sulfate eye drop and preparation method thereof

A technology of micronomycin and eye drops, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low cure rate and poor treatment effect, etc. Achieve high cure rate, low toxic and side effects, and simple process

Active Publication Date: 2010-08-04
LIAONING QIANLIMING PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available chloramphenicol eye drops have a certain therapeutic effect on bacterial conjunctivitis, but the therapeutic effect is not very good and the cure rate is low

Method used

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  • Micronomicin sulfate eye drop and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0044] The eye drops of this embodiment contain:

[0045] 3,000,000 units of micropromycin sulfate,

[0046] 8.0 grams of sodium chloride,

[0047] Sodium metabisulfite 2.0 grams,

[0048] 5.5 grams of hydroxypropyl cellulose with a concentration of 0.75% by weight,

[0049] 1000ml water for injection.

[0050] The preparation method is as follows: add 5.5 grams of hydroxypropyl cellulose aqueous solution with a concentration of 0.75% by weight to a container containing 400 ml of water for injection, stir and mix evenly, then add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite , After fully stirring and dissolving, add 3,000,000 units of micromycin sulfate, after dissolving, stirring and dissolving, adjust the pH to 7.0 with 0.5mol sodium hydroxide solution, add 600ml of water for injection to 1000ml of water for injection, use 0.22um micropore Sterilize the filter membrane.

Embodiment 2

[0052] The eye drops of this embodiment contain:

[0053] 3,000,000 units of micropromycin sulfate,

[0054] 8.0 grams of sodium chloride,

[0055] Sodium metabisulfite 2.0 g

[0056] 1000ml water for injection.

[0057] The preparation method is as follows: add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite to a 400ml water for injection container, fully stir to dissolve, add 3,000,000 units of micromycin sulfate, fully stir to dissolve, use 0.5mol Adjust the pH to 7.0 with sodium hydroxide aqueous solution, add 600ml of water for injection to 1000ml of water for injection, sterilize with 0.22μm microporous membrane.

Embodiment 3

[0059] The process and equipment of this embodiment are basically the same as in embodiment 1, except that the aqueous solution containing 2,000,000 units of micronomycin sulfate, 5.3 grams of sodium chloride, 1.3 grams of sodium metabisulfite, and a concentration of 0.03% by weight of hydroxypropyl cellulose 8 grams, 600 milliliters of water for injection.

[0060] The preparation method is as follows: adding 8 grams of an aqueous solution of hydroxypropyl cellulose with a concentration of 0.03% by weight to 240 milliliters of water for injection, adding the above amounts of sodium chloride, sodium metabisulfite and micronomycin sulfate, Adjust the pH to 6.0 with 0.3 mol sodium hydroxide aqueous solution, add 360 ml of water for injection, and sterilize with a 0.22 μm microporous membrane.

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Abstract

The invention relates to a micronomicin sulfate eye drop with micronomicin sulfate as a main component. The micronomicin sulfate eye drop can be used for curing eye diseases including bacterial conjunctivitis and the like, and contains micronomicin sulfate, sodium chloride, sodium metabisulfite and water for injection. The micronomicin sulfate eye drop also contains hydroxy propyl cellulose for achieving better curative effect. A preparation method comprises the following steps: adding the components into the water for injection, fully stirring and dissolving, adjusting a pH value to 6.8-7.2 through 0.3-0.5mol of sodium hydroxide aqueous solution, then adding a needed amount of water for injection, and filtering and sterilizing through a 0.22-micron microporous filtering film. The eye drop has a high curative ratio for the eye diseases, small side effects, simple process and equipment of the preparation method and little investment.

Description

1. Technical Field [0001] The invention relates to an eye drop for the treatment of eye diseases and a preparation method thereof, and more specifically to a micronnomicin sulfate eye drop (Micronnomicin Sulfate Eye Drops) with micronnomicin sulfate as the main component [0002] ) And its preparation method. 2. Background technology [0003] Bacterial conjunctivitis is still a common and frequently-occurring disease in ophthalmology, especially in rural areas, and is more common in spring and summer. For example, "pink eye disease" is prevalent, and there are many patients. Commercially available chloramphenicol eye drops have a certain therapeutic effect on bacterial conjunctivitis, but the therapeutic effect is not very good and the cure rate is low. 3. Summary of the invention [0004] The purpose of the present invention is to develop an eye drop with a higher cure rate for bacterial conjunctivitis and other external eye infections and to study its preparation method. [0005]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7036A61K47/02A61K47/38A61P27/02A61P31/02
Inventor 林继华
Owner LIAONING QIANLIMING PHARMA GROUP
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