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Medicament for treating orthopedics injuries and preparation method thereof

A drug and orthopedic technology, applied in the field of traditional Chinese medicine preparations, can solve problems such as odor, irritation, increased hygroscopicity, easy loss of volatile components, and affect the treatment effect, etc., to achieve improved taste, convenient storage, and easy patient acceptance Effect

Inactive Publication Date: 2010-02-17
BEIJING BORAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific surface area of ​​the medicine in the powder is larger after being pulverized, and its smell, taste, irritation, and hygroscopicity are correspondingly increased, and the volatile components are also more likely to be lost, thereby affecting the efficacy of the medicine and directly affecting the therapeutic effect.

Method used

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  • Medicament for treating orthopedics injuries and preparation method thereof
  • Medicament for treating orthopedics injuries and preparation method thereof
  • Medicament for treating orthopedics injuries and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental Example 1: Study on the crushing yield and sterilization method of medicinal materials

[0023] Take the prescribed amount of medicinal materials (except notoginseng and borneol), and grind them into the finest powder with a universal grinder; after freezing the Radix Notoginseng, grind them into the finest powder with a grinder, and grind the borneol into the finest powder separately. The results are shown in Table 1.

[0024] Table 1 The crushing yield and sterilization method of medicinal materials

[0025]

[0026] The test results show that the crushing yield of medicinal materials is about 97%, and it is sterilized by Co60 irradiation.

experiment example 2

[0027] Experimental Example 2: Selection of Excipients

[0028] Since the present invention is a pill made from raw powder, the prescription contains mineral medicine, animal medicine and resin medicinal materials. Without auxiliary materials, the production of medium-made soft materials is not effective, so consider adding suitable auxiliary materials as diluents to improve the viscosity of soft materials and increase the formability of pellets. Starch and microcrystalline cellulose are mostly used as diluents in production, so the two diluents are selected. The test methods and results are shown in Table 2.

[0029] Test method: Take 1 times the prescription amount of medicinal materials and crush them into the finest powder, add diluent to a total of 200g, use water as soft material, and make pills. The results are shown in Table 2.

[0030] Table 2 Choice of diluent

[0031] Types of accessories

[0032] The test results show that microcrystalline cellulose ha...

experiment example 3

[0033] Experimental example 3: Optimizing the type and dosage of wetting agent

[0034] According to the above preferred results, choose to add microcrystalline cellulose as an auxiliary material, and choose ethanol solutions with different concentrations as wetting agents. It is found in the test that ethanol is easy to volatilize, causing hardening of soft materials, which cannot be carried out smoothly when making pills; choose water for wetting Add the agent, spray it in, stir well and evenly to induce stickiness, and the soft material has good stickiness, does not stick to the wall, and the pellet shape is round, with less adhesion, and the pellets can be made smoothly.

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PUM

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Abstract

The invention discloses a medicament composition used for treating orthopedics injuries and a preparation method thereof, wherein the medicament composition comprises natural copper (roasted, quenching in vinegar), ground beeltle (liquorice-processed), rhubarb (wine-processed), drynaria rhizome, angelica tail (wine-processed), frankincense (roasted), myrrh (roasted), borax (roasted), dragon blood,pseudo-ginseng and borneol. The invention aims at replenishing the shortages of the prior drug preparation used for treating orthopedics injuries and providing a water-bindered pill which has smallerpill, and is easy to be swallowed and received by a patient. The preparation method for treating traumatic injuries comprises the following steps: crashing native copper and other ingredient of eleven ingredient except for pseudo-ginseng and borneol into fine powder; additionally taking pseudo-ginseng and borneol and respectively grinding into finest powder, mixing and grinding the finest powderand the fine powder, adding 30g of microcrystalline cellulose and appropriate amount of carboxymethyl starch sodium to reach the total amount of 200g, evenly mixing, adding water as wetting agent, evenly mixing, lumping for 5 minutes, making into pill strips, grading and rounding, drying, polishing, drying and split charging to form the finished product; and in order to guarantee the product quality, all operations are carried out in a clean and dry environment. The medicament composition is convenient for selecting dosages by patients, avoids the defects of poor mouthfeel and inaccurate taking dosages in the prior drugs; and meanwhile, the taking dosage is more accurate, the mouthfeel is greatly improved and easy to be received by patients, the production devices and technological requirements in pill making process are simple, and the concentrated pill prepared by a plastic method has high finished product ratio and stable quality.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, in particular to a medicine for treating orthopedic injuries. [0002] The present invention also relates to the preparation method of the above-mentioned medicine. Background technique [0003] Traumatic injuries are common diseases, and both hospitals and families have great demand. Daqilisan is an item in the ninth volume of "Standards of Chinese Patent Medicine of the Ministry of Health". It is a famous surgical prescription with the same reputation as Qilisan. Sex and price are also more suitable for the general public. The functions and indications of Daqili San are to remove blood stasis, reduce swelling, relieve pain and stop bleeding. It is mainly used for bruises, blood stasis and pain, and trauma to stop bleeding. However, after the powder is crushed, the specific surface area is larger, and its smell, taste, irritation, and hygroscopicity also increase acco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P19/08A61K31/045A61K33/22A61K33/26A61K35/64
Inventor 彭丽丽刘学静刘志勤黄成武
Owner BEIJING BORAN PHARM CO LTD
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