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Composite of natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant and nanometer iodine and preparation method thereof

A technology of natural polymers and graft copolymers, which is applied in the compound field of amphiphilic graft copolymers and iodine, and can solve problems such as immature and difficult iodine dispersion processes

Active Publication Date: 2011-08-31
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the difficulty in selecting materials with good clathrate stability for iodine, and the immature dispersion process of iodine, there are few literature reports on the preparation and application of nano-scale iodine and its derivatives.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 0.8:1 to 1,4-dioxane with a total mass ratio of 12:1, and disperse the iodine under the action of high-speed emulsification and stirring at 800 rpm. The pH of the solution system was adjusted to 4.5 by 5% dilute acetic acid solution. Add sodium dodecyl sulfonate with a mass ratio of 0.6:1 to iodine, emulsify and stir in a high-speed emulsification mixer at a speed of 800 rpm for 60 minutes to uniformly disperse the surfactant and iodine. The chitosan grafted poly(polyvinylpyrrolidone-copolymer-methyl acrylate) (the molar ratio of the two comonomers is 9:1) is weighed according to the mass ratio of iodine to 3:1, and then dissolved in the amphiphile. After forming a homogeneous solution in distilled water with a mass ratio of 5:1, the graft copolymer is added to the iodine / sodium dodecyl sulfonate surfactant composite solution, and emulsified and stirred at a speed of 800 revolutions per minute in a high-...

Embodiment 2

[0056] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 2.5:1 to tert-butanol with a total mass ratio of 8:1, disperse the iodine under the action of high-speed emulsification and stirring at 600 rpm, and pass through a 5% dilution. The acetic acid solution adjusts the pH of the solution system to 4.5. Add hexadecyltrimethylammonium chloride with a mass ratio of 0.8:1 to iodine, emulsify and stir in a high-speed emulsification mixer at a speed of 600 revolutions / minute for 120 minutes to uniformly disperse the long-chain alkyl surfactant and iodine. The carboxymethyl chitosan grafted poly(vinylpyrrolidone-co-vinyl acetate) (the molar ratio of the two comonomers is 8:2) is weighed at a mass ratio of 5:1 to the iodine, and then dissolved in After the amphiphilic graft copolymer is formed into a homogeneous solution in distilled water with a mass ratio of 5:1, add it to the iodine / hexadecyltrimethylammonium chloride composite solution, and in a high-speed emulsi...

Embodiment 3

[0058] Dissolve 1 part of iodine and potassium iodide with a mass ratio of 0.9:1 to the total mass ratio of potassium iodide in DMSO with a total mass ratio of 10:1, disperse the iodine under the action of high-speed emulsification stirring at 600 rpm, and pass through a 5% dilute acetic acid solution Adjust the pH of the solution system=5.5. Add dodecanol polyoxyethylene ether surfactant with a mass ratio of 0.4:1 to iodine, emulsify and stir in a high-speed emulsification mixer at a speed of 600 revolutions per minute for 60 minutes to make dodecanol polyoxyethylene ether surfactant Evenly dispersed with iodine. Graft chitosan with poly(vinylpyrrolidone-copolymer-sodium acrylate-copolymer-methyl acrylate) (the molar ratio of the three comonomers is 3:6:1) and weigh it at a mass ratio of 6:1 to iodine , Dissolved in distilled water with a mass ratio of 5:1 to the amphiphilic graft copolymer to form a uniform solution, then add iodine / dodecyl alcohol polyoxyethylene ether surf...

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Abstract

The invention provides a composite of natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant and nanometer iodine and preparation method thereof, wherein the preparation method comprises steps as follows: agitating-emulsifying the iodine, iodized salt and surfactant at high speed under a condition that the PH is 3.0-6.8 to form a composite solution, adding the natural macromolecule or the amphiphilic grafting copolymer of water-soluble derivant for further agitating-emulsifying and dispersing at high speed; and finally obtaining the composite of the natural macromolecule or amphiphilic grafting copolymer of water-soluble derivant with nanometer iodine. In comparison with the existing macromolecule-iodine composite, the composite is better in antibacterial effectand longer in function persistence, is capable of being used as antibacterial solution or recomposed into gelatine for usage as well as heated in vacuum and dried in freeze condition for usage after concentrated, or recomposed into corresponding preparation together with other secondary material after concentrated.

Description

Technical field [0001] The invention relates to a novel complex of amphiphilic graft copolymer of natural polymer or its water-soluble derivative and iodine, and a preparation method thereof. Background technique [0002] Iodine has a broad-spectrum antibacterial effect and strong antibacterial activity. However, because iodine is easy to sublime, iodine is usually compounded with various substrates to improve its stability and facilitate further use. Traditional iodine compounds such as povidone iodine, iodophor, iodine tincture, and iodine. Although these complexes have been used more commonly, it is still found that these complexes have a small amount of complexing with iodine, the uniformity of dispersion is difficult to ensure, the stability is not good, the iodine is easily lost, and it is The skin, especially the damaged mouth, is highly irritating, and the product produced has short shelf life and other defects. The applicant mentioned a new chitosan derivative-carboxym...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F251/02C08F289/00C08F253/00C08F8/18A61K31/79A61P31/00A61P31/12A01N59/12A01P1/00
Inventor 陈煜
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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