Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite

A technology of attapulgite and sustained-release capsules is applied in the field of Chinese patent medicine preparation, which can solve the problems of complicated operation, long production cycle and many steps, and achieve the effect of simplifying the operation steps and shortening the production cycle.

Inactive Publication Date: 2010-06-02
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of Ginkgo biloba extract or total flavonoids of Ginkgo biloba mostly adopts modern separation technology, and goes through steps such as extraction, resin adsorption, elution, and solvent recovery. This process has many steps, complicated operation, long production cycle, and high cost.
Traditional ginkgo biloba preparations are mostly common preparations. Since there is no sustained-release effect, the number of administrations is high, which brings inconvenience to patients and easily causes fluctuations in blood drug concentrations, which affects the curative effect of ginkgo biloba medicines.

Method used

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  • Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite
  • Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite
  • Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite

Examples

Experimental program
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Embodiment 1

[0023] Embodiment 1: CTMAB (cetyltrimethylammonium bromide) is dissolved in 10ml water, ultrasonically dissolves, makes the solution of 0.4mol / L, adds attapulgite 1.0g, ultrasonic 15min, suction filtration, washes to Bromide-free, dry at 105°C, grind finely, and pass through a 120-mesh sieve to obtain organically modified attapulgite; take 500 g of dried ginkgo leaves and grind them into 100-mesh coarse powder; add ginkgo leaf coarse powder and its weight 10 times of petroleum ether, reflux extraction for 1 hour to degrease, filter, and dry; degrease the degreased ginkgo leaf coarse powder with 10 times its weight in water for 3 times, each time for 1.5 hours, combine each decoction, filter, Concentrate to a relative density of 1.10; slowly add ethanol with a mass concentration of 95% to the concentrated solution while stirring to adjust the ethanol concentration to 70%, precipitate, let stand for 24 hours, filter, recover ethanol, and use the filtrate for later use; add the ab...

Embodiment 2

[0024] Embodiment 2: slowly dissolve 1.9g chitosan with HAc solution 100mL of 0.7% by volume fraction, be made into viscous chitosan colloid solution, chitosan colloid solution mixes with 32g attapulgite, stirs 48h to form chitosan Composite attapulgite paste, make it fully infiltrated, then place the paste in an oven to dry at 105°C, grind it finely, and pass through a 120-mesh sieve to obtain chitosan composite attapulgite; take 1000g of dried ginkgo leaves, Grind into 100-mesh coarse powder; add ginkgo leaf coarse powder and petroleum ether 10 times its weight in the container, reflux extraction for 1 hour to degrease, filter, and dry; extract the degreased ginkgo leaf coarse powder with water 10 times its weight for 3 times , the extraction time is 2 hours, 1 hour, and 1 hour respectively. The decoctions are combined, filtered, and concentrated to a relative density of 1.10; the concentrated solution is stirred while slowly adding ethanol with a mass concentration of 95% to...

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Abstract

The invention discloses a method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite, which comprises the following steps of: washing, drying and pulverizing gingko leaves into coarse powder; adding the gingko leaf coarse powder and petroleum ether with the weight ten times of the gingko leaf coarse powder into a container, refluxing and extracting for 1 hour, degreasing, filtering and drying; adding water with the weight ten times of the degreased gingko leaf coarse powder into the degreased gingko leaf coarse powder, boiling, decocting for 3 times, combining decocting liquids, filtering and concentrating to the relative density of 1.10; adding ethanol with the mass concentration of 95 percent into a concentrated liquid until the ethanol concentration is 70 percent, depositing, settling and filtering; adsorbing a filtrate through modified attapulgite to obtain the attapulgite loading total ginkgo flavone glycosides; and adding a pharmaceutical adjuvant material into the attapulgite loading total ginkgo flavone glycosides, and encapsulating into empty capsules to obtain the total ginkgo flavone glycosides slow-release capsules. The invention adopts the principle of adsorption separation and selects the modified attapulgite with strong adsorbability for the total ginkgo flavone glycosides to directly prepare a preparation without elution, the total ginkgo flavone glycosides slow-release capsules are slowly desorbed under the desorption action of a body fluid, steps are simplified, the production period is shortened, and the yield of products is improved.

Description

technical field [0001] The invention belongs to the field of preparation of Chinese patent medicines, and relates to a method for preparing sustained-release capsules of ginkgo leaf total flavonoids by using attapulgite, specifically, extracting active ingredients from traditional Chinese medicine ginkgo leaves by using modern Chinese medicine extraction and purification methods to prepare sustained-release capsules capsule. Background technique [0002] Ginkgo biloba L. is one of the oldest tree species on earth. Since the 1960s, scholars at home and abroad have conducted a lot of research on the chemical components and medicinal effects of Ginkgo biloba. It has a good effect, and the main active ingredient is ginkgo biloba flavonoids. [0003] The patent application with the application number 200810101001.X reviewed the research progress of the total flavonoids of Ginkgo biloba. Cardiovascular flow, anti-inflammatory, analgesic, anti-aging and other functions. The pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/52A61K47/02A61K47/16A61K47/36C01B33/40A61P9/10A61P9/12A61K127/00
Inventor 游庆红尹秀莲固旭赵玉萍吴洁
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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