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Chinese medicine composition for treating hepatic fibrosis, and preparation method and applications thereof

A liver fibrosis and composition technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of difficult treatment, poor prognosis, lack of anti-hepatic fibrosis drugs and the like

Active Publication Date: 2010-06-02
方步武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because Yin deficiency and blood stasis, blood heat and toxin accumulation syndrome are common in patients with active chronic liver disease complicated with liver fibrosis, such as chronic active hepatitis, chronic severe hepatitis, active liver cirrhosis, there are many cases, the condition is serious, and treatment is difficult. The prognosis is poor, and there is currently a lack of anti-hepatic fibrosis drugs for this syndrome; on the contrary, the currently marketed anti-hepatic fibrosis drugs are mainly for the syndrome of qi deficiency and blood stasis, and are mostly used in the quiescent phase of chronic liver diseases such as chronic persistent hepatitis, quiescent stage liver cirrhosis; therefore, this patent prescription is aimed at the fact that there is no medicine for the treatment of liver fibrosis with syndromes of yin deficiency, blood stasis, and blood-heat-toxin accumulation, and solves the problem of this large number of people. needs

Method used

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  • Chinese medicine composition for treating hepatic fibrosis, and preparation method and applications thereof
  • Chinese medicine composition for treating hepatic fibrosis, and preparation method and applications thereof
  • Chinese medicine composition for treating hepatic fibrosis, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0317] Artemisia annua 25 parts, turtle shell 15 parts, habitat 25 parts, Anemarrhena 25 parts, Danshen 35 parts, Polygonum cuspidatum 25 parts, Hedyotis diffusa 30 parts, Curcuma 25 parts, Eupatorium 25 parts. First decoct the turtle shell for 3 hours, then add other eight-flavored medicinal materials (artemisia annua, Anemarrhena, habitat, salvia, knotweed, hedyotis diffusa, turmeric, eupatorium), 8 times the amount of water to extract once, each time After 1 hour (orthogonal 1), the dregs were dried in the air, and extracted twice with 6 times the amount of 60% ethanol for 0.5 hours each time. Combine the filtrates, recover ethanol, concentrate the sample solution, dilute to the required concentration, and set aside.

Embodiment 2

[0319] 40 parts of Artemisia annua, 55 parts of turtle shell, 40 parts of habitat, 40 parts of Anemarrhena, 55 parts of Danshen, 40 parts of Polygonum cuspidatum, 55 parts of Hedyotis diffusa, 40 parts of turmeric, and 40 parts of Eupatorium. Extract the turtle shell and habitat with 10 times the amount of water for 3 times, each time for 1 hour (the best solution), and combine the filtrates. Extract other Qiwei herbs such as Polygonum cuspidatum and Salvia miltiorrhiza with 80% ethanol, extract 8 times the amount 3 times, 2 hours each time (the best solution), combine the filtrates, recover ethanol, concentrate the sample solution, dilute to the required concentration, and set aside.

Embodiment 3

[0321] 6 parts of Artemisia annua, 15 parts of Turtle Shell, 6 parts of Rehmannia, 6 parts of Anemarrhena, 15 parts of Salvia, 6 parts of Polygonum cuspidatum, 15 parts of Hedyotis diffusa, 6 parts of Curcuma, and 6 parts of Eupatorium. Take turtle shells and add appropriate amount of water to decoct for 2 hours, add other eight herbs, extract with 6 times the amount of water for 1 hour, filter, dry the medicinal residues, extract twice with 6 times the amount of 60% ethanol, 0.5 hours each time, Combine the filtrates, recover ethanol, concentrate to an appropriate amount, centrifuge, take the supernatant and filter, and fill the filtrate.

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Abstract

The invention discloses a Chinese medicine composition for treating and preventing chronic hepatic fibrosis and liver cirrhosis (wormwood-turtle yin-nourishing hardness-softening prescription), which comprises medicinal materials or active extracts thereof used as active ingredients, and a medicinal carrier. The Chinese medicine composition comprises 0.01-50 portions of sweet wormwood, 6-75 portions of turtle shell, 6-75 portions of radix rehmanniae, 6-50 portions of rhizoma anemarrhenae, 6-75 portions of radix salviae miltiorrhizae, 6-75 portions of giant knotweed, 6-75 portions of oldenlandia, 6-50 portions of radix curcumae and 6-50 portions of boneset. The wormwood-turtle yin-nourishing hardness-softening prescription composition of the invention has the functions of promoting blood circulation, resolving the hard lumps, nourishing yin, removing heat from the blood, clearing away heat, promoting diuresis and removing toxicity. The pharmacodynamic experimental result indicates that the Chinese medicine composition has the characteristics of high cure rate and obvious effect on hepatic fibrosis and liver cirrhosis caused by many reasons, such as chronic viral hepatitis, schistosomiasis, long-term drinking, chemical poisoning and the like. The Chinese medicine composition has favorable application prospects and is worthy of clinical popularization and application.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine composition for treating and preventing chronic liver disease liver fibrosis and liver cirrhosis, more specifically, the anti-hepatic fibrosis effect of the composition of "Haobie Yangyin Ruanjian Fang" and its preparation method and uses. Background technique [0002] Liver fibrosis is a pathological change characterized by increased extracellular matrix caused by various etiologies. It exists in the pathogenesis of various chronic liver diseases and is also one of the important factors affecting the prognosis of chronic liver diseases. Common causes of liver fibrosis include chronic viral hepatitis, heavy alcohol intake, schistosomiasis, etc. Viral hepatitis B and C are frequently-occurring diseases in my country. Alcoholic liver disease is increasing year by year. Liver damage is caused by sporadic schistosomiasis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16A61P31/14A61P31/20A61P33/12A61K35/56A61K31/357A61K31/366A61K35/32A61K35/586
CPCY02A50/30
Inventor 方步武
Owner 方步武
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