Human epididymis expression sperm binding protein HEL-122 as well as coding gene and application thereof

A technology of HEL-122 and binding protein, which is applied in the fields of anti-peptide protease inhibitor immunoglobulin, application, gene therapy, etc., can solve the problem of rare biological functions of recombinant protein of epididymis protease inhibitor, and achieve less side effects
CN101724067AInactive Publication Date: 2010-06-09李建远
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
李建远
Publication Date
2010-06-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biology technology and medicine, and discloses a new human epididymis expression sperm binding protein HEL-122 as well as preparation and application thereof. The invention discloses an amino acid sequence of the HEL-122 protein and provides a recombination expression vector carrying a DNA sequence for coding the protein. The invention also discloses the preparation of the protein and a method for detecting the biology function of the HEL-122 protein. The protein is specifically expressed in the epididymis, and the expression quantity is highest in the epididymis part, and the protein is bound to the equator of the sperm to play a significant role in sperm fertilization. The HEL-122 protein can be used as a targeted protein for researching immunity contraceptives, and clinically diagnosing and treating male infertility. A corresponding gene or protein detection method developed based on the HEL-122 protein can be widely applied to the field of reproductive medicine research.
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Description

technical field

[0001] The invention relates to the fields of biotechnology and medicine. The invention provides a novel human epididymis-specifically expressed sperm-binding protein HEL-122, and discloses the amino acid sequence encoding the HEL-122 protein and the DNA sequence encoding the protein. The invention also discloses the preparation and detection method of the protein, as well as the biological function. This protein plays an important role in sperm maturation, normal fertilization and early embryonic development. The HEL-122 protein can be used as a target protein for the research and development of immune contraceptives, as well as the clinical diagnosis and treatment of male infertility. The research and development of this protein is of great significance to male reproductive medicine. Background technique

[0002] Immunological contraception has been studied for many years as a reversible non-hormonal therapy, and the research focuses on preventing pregna...

Claims

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