Medicinal fibre used for treating cutaneous inflammation and pain, preparation and application thereof

Abstract

The invention relates to medicinal fibre used for treating cutaneous inflammation and pain, which comprises the components of cellulose acetate nano fibre, a ketoprofen ester precursor medicine and a medicinal percutaneous sorbefacient, wherein the ketoprofen ester precursor medicine accounts for 0.1-30% of the total weight of the fibre, the medicinal percutaneous sorbefacient accounts for 0.1-10% of the total weight of the fibre, and the cellulose acetate nano fibre accounts for 1-99% of the total weight of the fibre; the preparation of the medicinal fibre comprises the following steps: dissolving the ketoprofen ester precursor medicine, the medicinal percutaneous sorbefacient and the cellulose acetate into an organic solvent to prepare spinning liquid and then spinning to prepare the required medicinal fibre. The medicinal fibre has the effect of treating cutaneous inflammation and pain, has simple preparation method, convenient source of the raw materials and low cost, is friendly to the environment and is suitable for industrialized production; the fibre can be prepared into medicine-carrying clothings or other fabrics which directly contact with the skin of a human body, and the percutaneous administration is safe and comfortable.

Description

technical field

[0001] The invention belongs to the field of medicinal fiber and its preparation and application, in particular to a medicinal fiber for treating skin inflammation and pain and its preparation and application. Background technique

[0002] The skin is the main barrier for drug transdermal absorption. Current research is mainly focused on overcoming the barrier function of the stratum corneum of the skin and screening drug transdermal absorption enhancers. However, the skin also has a rich enzyme system, and the drug will inevitably come into contact with the biotransformation system during the transdermal absorption process, and biotransformation behaviors such as activation, inactivation, or reaction with tissue components may occur. The study of percutaneous absorption is of great significance. As an important method to improve the percutaneous absorption characteristics of drugs, prodrugs have been highly valued, mainly based on the conversion of metaboli...

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