Medicinal fibre used for treating cutaneous inflammation and pain, preparation and application thereof

Abstract

The invention relates to medicinal fibre used for treating cutaneous inflammation and pain, which comprises the components of cellulose acetate nano fibre, a ketoprofen ester precursor medicine and a medicinal percutaneous sorbefacient, wherein the ketoprofen ester precursor medicine accounts for 0.1-30% of the total weight of the fibre, the medicinal percutaneous sorbefacient accounts for 0.1-10% of the total weight of the fibre, and the cellulose acetate nano fibre accounts for 1-99% of the total weight of the fibre; the preparation of the medicinal fibre comprises the following steps: dissolving the ketoprofen ester precursor medicine, the medicinal percutaneous sorbefacient and the cellulose acetate into an organic solvent to prepare spinning liquid and then spinning to prepare the required medicinal fibre. The medicinal fibre has the effect of treating cutaneous inflammation and pain, has simple preparation method, convenient source of the raw materials and low cost, is friendly to the environment and is suitable for industrialized production; the fibre can be prepared into medicine-carrying clothings or other fabrics which directly contact with the skin of a human body, and the percutaneous administration is safe and comfortable.

Description

technical field

[0001] The invention belongs to the field of medicinal fiber and its preparation and application, in particular to a medicinal fiber for treating skin inflammation and pain and its preparation and application. Background technique

[0002] The skin is the main barrier for drug transdermal absorption. Current research is mainly focused on overcoming the barrier function of the stratum corneum of the skin and screening drug transdermal absorption enhancers. However, the skin also has a rich enzyme system, and the drug will inevitably come into contact with the biotransformation system during the transdermal absorption process, and biotransformation behaviors such as activation, inactivation, or reaction with tissue components may occur. The study of percutaneous absorption is of great significance. As an important method to improve the percutaneous absorption characteristics of drugs, prodrugs have been highly valued, mainly based on the conversion of metaboli...

Examples

Embodiment 1

[0028] In the present embodiment, ketoprofen isopropyl ester, drug transdermal absorption accelerator laurocapram and cellulose acetate are dissolved in acetone and N, N-dimethylacetamide (acetone and N, N-dimethyl The volume ratio of acetamide 2 / 1) in the solvent, stir under normal temperature, get spinning solution: wherein, the add-on of ketoprofen isopropyl ester is 8% of spinning solution weight, and the add-on of laurocaprazine is 3% of the spinning solution weight, the addition of cellulose acetate is 25% of the spinning solution weight; then the spinning solution containing ketoprofen isopropyl ester and laurocaprazine is made into fiber by wet spinning process ; use the obtained fibers to weave cloth according to the weaving process of existing fabrics, and then make the cloth into textile underwear according to the weaving process of ordinary fabrics, then the fabric of the underwear contains both cellulose acetate and ketoprofen isocyanate. Propyl ester and drug tra...

Embodiment 2

[0030] In the present embodiment, with acetone and N,N-dimethylacetamide (volume ratio 2 / 1) as solvent, the weight content of cellulose acetate in the spinning solution is 50%, the add-on of ketoprofen isopropyl ester It is 15% of spinning solution weight, and the addition of drug transdermal absorption accelerator propylene glycol (used in conjunction with oleic acid, propylene glycol / oleic acid volume ratio is 1 / 2) is 6.5% of spinning solution weight. The dry-wet spinning process is adopted in the fiber-forming procedure, and the other methods are the same as in Example 1, and textile socks can be produced, which have the functions of treating various arthritis and relieving postoperative pain.

Embodiment 3

[0032] In the present embodiment, with acetone, N, N-dimethylacetamide and ethanol (volume ratio 4 / 1 / 1) as solvent, the weight content of cellulose acetate solution in the spinning solution is 10%, ketoprofen iso The addition of propyl ester is 2% of the weight of the spinning solution, the addition of the drug transdermal absorption accelerator menthol is 2.5% of the weight of the spinning solution, and the high-voltage electrostatic spinning process is used in the process of making fibers from the spinning solution , other methods are identical with embodiment 1, can make the textile glove, and this glove has functions such as treating various arthritis and alleviating postoperative pain.

technical field

[0001] The invention belongs to the field of medicinal fiber and its preparation and application, in particular to a medicinal fiber for treating skin inflammation and pain and its preparation and application. Background technique

[0002] The skin is the main barrier for drug transdermal absorption. Current research is mainly focused on overcoming the barrier function of the stratum corneum of the skin and screening drug transdermal absorption enhancers. However, the skin also has a rich enzyme system, and the drug will inevitably come into contact with the biotransformation system during the transdermal absorption process, and biotransformation behaviors such as activation, inactivation, or reaction with tissue components may occur. The study of percutaneous absorption is of great significance. As an important method to improve the percutaneous absorption characteristics of drugs, prodrugs have been highly valued, mainly based on the conversion of metaboli...

Examples

Embodiment 1

[0028] In the present embodiment, ketoprofen isopropyl ester, drug transdermal absorption accelerator laurocapram and cellulose acetate are dissolved in acetone and N, N-dimethylacetamide (acetone and N, N-dimethyl The volume ratio of acetamide 2 / 1) in the solvent, stir under normal temperature, get spinning solution: wherein, the add-on of ketoprofen isopropyl ester is 8% of spinning solution weight, and the add-on of laurocaprazine is 3% of the spinning solution weight, the addition of cellulose acetate is 25% of the spinning solution weight; then the spinning solution containing ketoprofen isopropyl ester and laurocaprazine is made into fiber by wet spinning process ; use the obtained fibers to weave cloth according to the weaving process of existing fabrics, and then make the cloth into textile underwear according to the weaving process of ordinary fabrics, then the fabric of the underwear contains both cellulose acetate and ketoprofen isocyanate. Propyl ester and drug tra...

Embodiment 2

[0030] In the present embodiment, with acetone and N,N-dimethylacetamide (volume ratio 2 / 1) as solvent, the weight content of cellulose acetate in the spinning solution is 50%, the add-on of ketoprofen isopropyl ester It is 15% of spinning solution weight, and the addition of drug transdermal absorption accelerator propylene glycol (used in conjunction with oleic acid, propylene glycol / oleic acid volume ratio is 1 / 2) is 6.5% of spinning solution weight. The dry-wet spinning process is adopted in the fiber-forming procedure, and the other methods are the same as in Example 1, and textile socks can be produced, which have the functions of treating various arthritis and relieving postoperative pain.

Embodiment 3

[0032] In the present embodiment, with acetone, N, N-dimethylacetamide and ethanol (volume ratio 4 / 1 / 1) as solvent, the weight content of cellulose acetate solution in the spinning solution is 10%, ketoprofen iso The addition of propyl ester is 2% of the weight of the spinning solution, the addition of the drug transdermal absorption accelerator menthol is 2.5% of the weight of the spinning solution, and the high-voltage electrostatic spinning process is used in the process of making fibers from the spinning solution , other methods are identical with embodiment 1, can make the textile glove, and this glove has functions such as treating various arthritis and alleviating postoperative pain.

Images