New application of natural product amentoflavone in treating cancers

A kind of technology of biflavonoids and cancer, which is applied in the field of medicine, can solve the problems such as no related reports, and achieve the effect of broad market prospects, huge economic benefits and social benefits

Inactive Publication Date: 2010-06-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the role of biflavones in the treatment of cancer.

Method used

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  • New application of natural product amentoflavone in treating cancers
  • New application of natural product amentoflavone in treating cancers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: The inhibitory effect of amentoflavone on the pair.

[0013] Method: MMT method was used. Operation steps: HCT-8, Bel-7402, A549, and A2780 cell lines in logarithmic growth phase were respectively inoculated on 96-well plates with 2×104 / well cells, and different concentrations of DMTCCI were added. Set the 0.1% DMSO control group to culture for 72 hours, add 5mg / ml MTT10ul to each well 4 hours before the end of the culture. Bio-RadModel 550Microplate Reader measures the OD value at a wavelength of 570nm. And calculate IC50.

[0014] result:

[0015] MTT Screening Results

[0016]

Embodiment 2

[0018] Take 50 g of amentoflavone, add 150 g of fine starch powder, mix evenly with the method of equal increments, add 5 g of talcum powder, 2 g of magnesium stearate, mix evenly, granulate with 85% ethanol, dry, granulate, Compressed into 1000 tablets, 3 times a day, 2 tablets each time.

Embodiment 3

[0020] Take 50g of amentoflavone, add 200g of fine starch powder, 10g of talcum powder, and 5g of magnesium stearate, mix well, granulate, dry, put into capsules, and make 1000 capsules, 3 times a day, each time 2 tablets.

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Abstract

The invention discloses new application of a natural product amentoflavone in treating cancers. The natural product amentoflavone is extracted from plants, Chinese medicinal materials or Chinese medicaments prepared in ready-to-use forms containing the amentoflavone. The compound serves as a pharmacodynamic component to prepare medicament preparations for treating the cancers, and can be independently or combined with an excipient acceptable in the pharmaceutical technology to be prepared into the medicament preparations such as tablets, capsules, granules, sustained release preparations and pills for oral administration, gels and suppositories administrating through orifices such as vagina, anus and nasal cavity, and intramuscular or intravenous injections. The content of the amentoflavone in the medicament preparations is over 90 percent. The invention discloses the pharmacodynamic component of a Chinese medicament tamariskoid spikemoss herb for treating the cancers, and provides a scientific basis for clinical application, so the amentoflavone can serve as a natural anticancer agent and has the characteristics of no addiction and low dosage.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a new application of amentoflavone in the pharmaceutical field, in particular to a new application of amentoflavone in treating cancer. Background technique: [0002] According to the statistics of the World Health Organization (WHO), 6 million people die from cancer every year in the world, and there are about 10 million new cases every year. According to the statistics of relevant departments in our country, 1.3 million people die of cancer every year, about 1.6 million new cases occur, and the annual economic damage reaches 100 billion yuan. [0003] According to the "Latest Ranking of Causes of Death in China" provided by the National Cancer Prevention and Research Office, the death rate of malignant tumors ranks second among all causes of death. Due to the serious pollution of the earth's environment and changes in diet and lifestyle, malignant tumors have a further upward t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
Inventor 张国刚田宏
Owner SHENYANG PHARMA UNIVERSITY
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