Drug combination synergistic effect determination method based on gene network

A gene network and drug action technology, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of complex experimental links, huge combination space, high cost, etc., and achieve accurate results, strong applicability, and low cost. low effect

Active Publication Date: 2010-06-23
TSINGHUA UNIV
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Problems solved by technology

However, in the current field of drug research and development, the method of measuring the strength of synergy between drugs is mainly done through in vivo and in vitro experimental research. Due to the huge combination space, the experimental process is complicated and the cost is high.

Method used

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  • Drug combination synergistic effect determination method based on gene network
  • Drug combination synergistic effect determination method based on gene network
  • Drug combination synergistic effect determination method based on gene network

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The inventors used the NIMS method to screen anti-angiogenesis drug combinations. There are 63 candidate drugs, and 63 candidate drugs form 63*(63-1) / 2=1953 drug combinations. The implementation effect is as follows:

[0065] The 63 drug candidates included two drug combinations known to have anti-angiogenic interactions: 5-fluorouracil+vinblastine, and 5-fluorouracil+rapamycin. Predicted by NIMS method, among all 1953 combinations, these two drug combinations known to have synergistic effects are all in the top three (see Table 1), and the results of the three gene networks are basically consistent. This example demonstrates the effectiveness of the NIMS method, which is capable of well finding drug combinations known to have synergistic effects.

[0066] Table 1. NIMS predictive ranking of known synergistic drug combinations among 1953 drug combinations

[0067]

[0068] Validation of Cell Proliferation Assays for Definitive Results of NIMS Methods

[0069] Taki...

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Abstract

Disclosed is a method for determining the drug combination synergistic effect of two drugs related to a disease according to gene network and drug effective gene; the method includes that: the synergistic factors (ST1, 2) of the two drugs are determined; the drug similarity factors (AS1, 2) of the two drugs are determined; the drug combination synergistic effect of the two drugs is determined according to the product of the synergistic factors and the similarity factors. The invention can construct the disease gene network according to specific disease under research, and maps the gene of each drug effect or gene product to the network for quantitatively measuring the synergy degree of the drugs, and has the advantages of high speed, low cost and accurate results.

Description

technical field [0001] A gene network-based drug combination synergy determination method (Network-based Identification for Multicomponent Synergy, hereinafter also referred to as "NIMS method"), which is mainly used in the field of drug research and development, to measure the synergistic effect of two drugs on a certain disease (Synergistic The strength of effect) can be given quantitatively, and the synergistic effect of the drug combination is effectively screened before the experimental study. Background technique [0002] The development of drug combinations with synergistic effects is a new way to treat many diseases at present; the so-called synergistic effect (Synergistic effect) means that the effect of two drugs in combination is greater than the sum of the effects of the two drugs alone at the same dose. In the applicant's Chinese patent application No. 200610114226.X (authorized), a combination of pharmaceutical ingredients with synergistic effects is described,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 李梢张宁波张博
Owner TSINGHUA UNIV
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