Mother liquid recovery process for 7-aminocephalosporanic acid production

A technology for recovery of aminocephalosporanic acid and mother liquor, applied in organic chemistry, fermentation, etc., can solve problems such as waste and aggravation of environmental pollution, and achieve the effects of COD reduction, huge social benefits, and protection of water sources and the surrounding environment

Active Publication Date: 2010-07-07
焦作健康元生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If this part of the residual liquid is directly discharged, it will not only cause waste, but also aggravate environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The mother liquor recovery process that is used in the production of 7-aminocephalosporanic acid comprises the following steps:

[0022] a. After the centrifuged mother liquor is collected, adjust the pH to 7.0 with alkali and lower the temperature to 8 degrees Celsius;

[0023] b. Concentrate the centrifuged mother liquor with adjusted pH through membrane filtration equipment, the temperature is 8 degrees Celsius, and the concentration ratio is 10 times;

[0024] c. Depigmenting the concentrated feed liquid through activated carbon;

[0025] d. The decolorized feed liquid enters the acylation tank, and uses an acylase to carry out a cleavage reaction at a temperature of 19 degrees Celsius at a pH of 7.5, and re-cracks the unreacted glutaryl 7-aminocephalosporanic acid in the feed liquid into 7-aminocephalosporanic acid;

[0026] e. Filter out the acylase from the cleavage reaction solution, lower the temperature to 8 degrees Celsius, slowly add hydrochloric acid to c...

Embodiment 2

[0029] The mother liquor recovery process that is used in the production of 7-aminocephalosporanic acid comprises the following steps:

[0030] a. After the centrifuged mother liquor is collected, adjust the pH to 8.0 with alkali, and lower the temperature to 0 degrees Celsius;

[0031] b. Concentrate the centrifuged mother liquor with adjusted pH through membrane filtration equipment, the temperature is 0 degrees Celsius, and the concentration ratio is 15 times;

[0032] c. Depigmenting the concentrated feed solution through an alumina column;

[0033] d. The decolorized feed liquid enters the acylation tank, and uses an acylase to carry out a cleavage reaction at a temperature of 28 degrees Celsius at a pH of 8.5, and re-cracks the unreacted glutaryl 7-aminocephalosporanic acid in the feed liquid into 7-aminocephalosporanic acid;

[0034] e. Filter out the acylase from the cleavage reaction solution, lower the temperature to 0 degrees Celsius, slowly add sulfuric acid to c...

Embodiment 3

[0037] The mother liquor recovery process that is used in the production of 7-aminocephalosporanic acid comprises the following steps:

[0038] a. After the centrifuged mother liquor is collected, adjust the pH to 7.5 with alkali and lower the temperature to 4 degrees Celsius;

[0039] b. Concentrate the centrifuged mother liquor with adjusted pH through membrane filtration equipment, the temperature is 4 degrees Celsius, and the concentration ratio is 13 times;

[0040] c. Depigmenting the concentrated feed liquid using a resin column, preferably at a temperature of 3 degrees Celsius, for depigmentation treatment;

[0041] d. The decolorized feed liquid enters the acylation tank, and uses an acylase to carry out a cleavage reaction at a temperature of 22 degrees Celsius at a pH of 8.0, and re-cracks the unreacted glutaryl 7-aminocephalosporanic acid in the feed liquid into 7-aminocephalosporanic acid;

[0042] e. Filter out the acylase from the cleavage reaction solution, l...

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Abstract

The invention provides a mother liquid recovery process for 7-aminocephalosporanic acid production, which comprises the following steps of: a. after being collected, adjusting pH of centrifugal mother liquid to be 7.0 to 8.0 with alkali, reducing the temperature to be 0 to 8 DEG C; b. concentrating the pH-adjusted centrifugal mother liquid with the concentration time of 10 to 15 times; c. treating concentrated liquid with depigmentation; d. placing the depigmented into an acylation tank, using acylase to have cracking reaction under the condition of pH equal to 7.5 to 8.5 and the temperature of 19 to 28 DEG C, and re-cracking non-fully reacted glutaryl 7-aminocephalosporanic acid in the liquid into 7-aminocephalosporanic acid; e. filtering acylase from the cracking reaction liquid, reducing the temperature to be 0 to 8 DEG C, and slowly adding acid for crystallization; f. carrying out solid-liquid separation for crystal with a centrifugal machine, washing the obtained crystal with water or organic solvent, and drying under the temperature of 40 to 50 DEG C.

Description

technical field [0001] The invention belongs to a mother liquor recovery process used in the production of 7-aminocephalosporanic acid. Background technique [0002] The English abbreviation of 7-aminocephalosporanic acid is 7-ACA, which is an important intermediate for domestic production of cephalosporin antibiotics. In China, chemical methods are generally used to produce 7-ACA, and some manufacturers use enzymatic methods to produce 7-ACA. When 7-ACA is produced by enzymatic method, the 7-ACA in the reaction feed liquid is crystallized out, and after the crystallization is separated by solid-liquid separation equipment, some products and unfinished reactants still remain in the remaining mother liquor, with a content of about At 800-1000mg / L. If this part of residual liquid is discharged directly, it will not only cause waste, but also aggravate environmental pollution. Contents of the invention [0003] The object of the present invention is to provide a kind of mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/18C12P35/02
Inventor 乔晓光江国华
Owner 焦作健康元生物制品有限公司
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