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Mesenchymal stem cell biological winkle removing agent and preparation method thereof

A technology of mesenchymal stem cells and anti-wrinkle agents, which is applied in the field of mesenchymal stem cell biological anti-wrinkle agents and its preparation, can solve problems that do not conform to the physiological characteristics of the skin, tissue stiffness, etc., and achieve anti-aging skin, eliminate wrinkles, and maintain time. long effect

Active Publication Date: 2013-02-27
晏泽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aibeifu mainly contains bovine collagen and microspheres. In the early stage, bovine collagen is used to achieve the effect. In the long-term effect, the foreign body reaction of the microspheres stimulates fibroblasts to synthesize collagen to achieve the purpose of wrinkle removal. Physiological characteristics

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] A mesenchymal stem cell biological anti-wrinkle agent, which is uniformly mixed with mesenchymal stem cells, recipient plasma, growth factors, insulin and hyaluronic acid.

[0019] Wherein: the mesenchymal stem cells may be bone marrow mesenchymal stem cells, umbilical cord mesenchymal stem cells or placental mesenchymal stem cells collected and cultured under sterile conditions. Growth factors include basic fibroblast growth factor, epidermal growth factor, and vascular endothelial growth factor. Each 5ml total amount of mesenchymal stem cell biological wrinkle remover contains 1×10 7 About one mesenchymal stem cell, plasma 2-3ml, add 10μg / L basic fibroblast growth factor, 5μg / L epidermal growth factor, 10μg / L vascular endothelial growth factor, and 10μM insulin.

[0020] The preparation method of mesenchymal stem cell biological anti-wrinkle agent, calculated according to the total amount of preparation 5ml, comprises the following steps:

[0021] ⑴ Collect and cult...

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PUM

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Abstract

The invention discloses a mesenchymal stem cell biological winkle removing agent and a preparation method thereof. The winkle removing agent is prepared by uniformly mixing mesenchymal stem cells, recipient blood plasma, growth factors, insulin and hyaluronic acid. The preparation method comprises the following steps of: (1) collecting and culturing the mesenchymal stem cells to prepare cell concentrated solution; (2) collecting the recipient blood plasma; (3) adding the growth factors and the insulin into the recipient blood plasma; and (4) using the hyaluronic acid as a biologic scaffold, and repeatedly sucking and uniformly mixing 2 percent hyaluronic acid, the blood plasma into which the growth factors and the insulin are added and the mesenchymal stem cell concentrated solution in an injector to obtain a mesenchymal stem cell preparation. The winkle removing agent prepared by the method is used for removing and preventing skin winkles and has the advantages of quick response, long maintenance time, non-stiff facial expression, unobvious hardening of hyperplastic tissues and skin texture accordant with normal skin.

Description

technical field [0001] The invention relates to the technical field of stem cell application, in particular to a mesenchymal stem cell biological wrinkle remover for eliminating skin wrinkles and a preparation method thereof. Background technique [0002] After skin aging, the number of fibroblasts decreases, the function declines, the synthesis of skin collagen and hyaluronic acid decreases, and the degeneration and aging of collagen and elastic fibers are the main reasons for skin aging, atrophy, thinning and wrinkles. For skin wrinkles, there are currently two main ways, surgical wrinkle removal and injection wrinkle removal. Surgical wrinkle removal is effective, but it has high risks and many complications, and the general acceptance rate is low. There are mainly two methods of injecting wrinkle reduction: injecting botulinum toxin and injecting fillers. Botulinum toxin achieves the purpose of wrinkle removal by paralyzing the facial muscles, and has quick results, bu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61K35/28A61K35/44A61K35/50A61P17/16A61L27/60A61K31/728A61K35/16A61K38/18
Inventor 晏泽
Owner 晏泽