Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing betaine hydrochloride

A technology of hydrochloride and betaine, which is applied in the preparation of organic compounds, chemical instruments and methods, and cyanide reaction preparation, etc. It can solve the problems of difficult to remove salt, impurities in products, and consume large energy, so as to save raw materials , short production cycle, and the effect of reducing energy consumption

Inactive Publication Date: 2015-03-04
赵学知
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has a mild reaction, but the reaction is carried out in an aqueous solution, and a large amount of energy is consumed during concentration; the salt generated is difficult to remove, and there are impurities in the product; and the discharge of salt water is also a big problem; due to the post-processing problem, The production cycle of this process is generally about 30 hours
At present, there is no report on the method of directly reacting chloroacetic acid and trimethylamine to generate betaine hydrochloride without going through the water environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Before the reaction, the content of water in chloroacetic acid and trimethylamine was determined. It is determined that the water content of chloroacetic acid is 0.5 wt%, and the water content of trimethylamine is 0.5 wt%.

[0023] Put 232ml of chloroform into the reaction kettle, start stirring, then add 94.5g of solid chloroacetic acid into the reaction kettle, control the temperature at 30°C and slowly feed 59.1g of gaseous trimethylamine, and keep the gauge pressure of the reaction kettle after passing through 0.1MPa, stirring and heat preservation reaction for 6 hours, after the reaction, cool down to 25°C, stand still for crystallization, and then centrifuge, the centrifuged product is then crystallized in water, washed with chloroform after crystallization, and dried to obtain 90.4g Betaine hydrochloride with perfect crystal form, organic solvent and raw materials are recycled.

Embodiment 2

[0025] Put 346ml of DMF into the reactor, start stirring, then add 141.7g of chloroacetic acid with a water content of 1wt% into the reactor, control the temperature at 40°C and slowly feed 88.6g of trimethylamine with a water content of 1wt%, and Finally, keep the gauge pressure of the reactor at 0.2MPa, stir and heat-preserve for 8 hours, cool to 25°C after the reaction, let it stand for crystallization, then centrifuge, wash with DMF, and dry to obtain 92g of betaine hydrochloride, organic solvent and raw materials Cycle through.

Embodiment 3

[0027] Before the reaction, the water content of chloroacetic acid and trimethylamine was determined to be 1 wt%, respectively, and the amount of raw materials required for the reaction was obtained according to the molar ratio of chloroacetic acid to trimethylamine and the molar ratio of water content to water removal agent. The operation steps are as follows:

[0028] Put 308ml of toluene into the reactor, start stirring, then add 80g of chloroacetic acid with a water content of 1wt% in the reactor, then add 15.9g of chloroacetic anhydride, control the temperature at 45°C and slowly feed 59.1g of chloroacetic acid with a water content of 1wt% trimethylamine, keep the gauge pressure of the reactor at 0.1MPa after passing through, stir and heat-preserve for 5 hours, cool down to room temperature after the reaction, stand for crystallization, then centrifuge, crystallize in water, wash with toluene, and dry to obtain 120.2 g betaine hydrochloride, organic solvents and raw mater...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing betaine hydrochloride. In the method, chloroacetic acid, trimethylamine and a water removing agent are used as raw materials and reacted in an organic solvent to prepare the betaine hydrochloride. The method comprises the following specific processing steps: putting the organic solvent into a reaction kettle; starting the reaction kettle to stir the organic solvent; adding the chloroacetic acid and the water removing agent and introducing the trimethylamine for reaction at a certain temperature; and after the reaction is finished, cooling, crystallizing, centrifuging, cleaning and drying to obtain the betaine hydrochloride. The method has the advantages of reduction in production cost because two raw materials are saved, no other by-products in the product, no waste discharge, reduction in energy consumption, simple process, short production period, mild reaction condition, easy realization of big industrial production, stable product quality, and recyclable raw materials and solvent.

Description

technical field [0001] The invention relates to a preparation method of betaine hydrochloride, in particular to a preparation method of betaine hydrochloride in anhydrous environment. Background technique [0002] The chemical name of betaine hydrochloride is trimethylglycine hydrochloride. It is a good feed additive that can participate in fat metabolism and promote protein synthesis; it has food-attracting activity and promotes the growth of animals; it has synergy with anticoccidial drugs Function, improve curative effect; provide methyl, as methyl donor, reduce feed cost. There is a great demand for betaine hydrochloride in our country, and the market is broad. [0003] At present, the production of betaine hydrochloride is carried out in an aqueous solution. Generally, chloroacetic acid is first reacted with an alkaline sodium salt solution to form sodium chloroacetate, and then excessive trimethylamine is passed into the aqueous solution of sodium chloroacetate to ful...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/12C07C227/08
Inventor 赵学知
Owner 赵学知
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com