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Traditional Chinese medicine composite for antibiosis and antiphlogosis

An antibacterial, anti-inflammatory and combination technology, applied in the directions of antibacterial drugs, drug combinations, anti-inflammatory agents, etc., can solve the problems of increased drug resistance frequency and the inability of antibiotics to meet clinical needs, and achieves stable quality, easy quality control, and compatible ingredients. clear effect

Inactive Publication Date: 2010-08-11
HUNAN JIUDIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, people's long-term and extensive use of antibiotics has led to continuous enhancement of bacterial resistance, and the frequency of drug resistance has gradually increased, so that conventional antibiotics cannot meet clinical needs

Method used

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  • Traditional Chinese medicine composite for antibiosis and antiphlogosis
  • Traditional Chinese medicine composite for antibiosis and antiphlogosis
  • Traditional Chinese medicine composite for antibiosis and antiphlogosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Weigh 2100g of Scutellaria baicalensis, 60g of berberine (equivalent to 1200g of berberine) and 150g of berberine (equivalent to 2700g of rhizome), and prepare capsules as follows:

[0053] A. Weigh Scutellaria baicalensis according to the proportion, add water to soak for 3 hours, decoct 3 times, each time for 1.5 hours. Concentrate the filtrate to 5 times of the feeding amount, adjust the pH to 2-3, keep the temperature at 75°C for 1h, let it stand for 24h, wash the precipitate with water to pH5.5, continue to wash with 78% ethanol to pH6.8, and dry at low temperature. That is to get baicalin;

[0054] B. Mix the baicalin obtained in A with berberine and palmatine, and add corresponding auxiliary materials sucrose, microcrystalline cellulose, starch, etc. to prepare 1000 capsules.

Embodiment 2

[0056] Weigh 140g of baicalin (equivalent to 2150g of Scutellaria baicalensis), 2150g of berberine rhizome and 200g of palmatine (equivalent to 4150g of scutellaria vine), respectively, and prepare tablets as follows:

[0057] A. Weigh Coptidis Rhizome in proportion, crush it, add 9 times the volume of 50% ethanol to soak for 1 hour, reflux twice, each time for 1h (temperature 60°C), collect the reflux liquid, filter it while it is hot, and put the filtrate into a rotary evaporator Concentrated until almost alcohol-free. The concentrated solution was adjusted to pH 1-2 with concentrated hydrochloric acid, left overnight, filtered, precipitated, and dried.

[0058] B. Pulverize and grind the berberine hydrochloride obtained in A into powder, mix it with baicalin and palmatine, add corresponding auxiliary materials sucrose, magnesium stearate, sodium lauryl sulfate, hydroxypropyl methylcellulose, etc., Granulation, sizing, mixing, drying, tableting. Prepare 1000 tablets.

Embodiment 3

[0060] Weigh 175g of baicalin (equivalent to 4800g of Scutellaria baicalensis), 30g of berberine (equivalent to 600g of berberine) and 35g of palmitine (equivalent to 600g of rhizoma rhizome), crush the three, add suitable auxiliary materials microcrystalline cellulose, pre- Gelatinized starch, Tween-80, polyvinylpyrrolidone, etc., granulated, sized, mixed, dried, filled into ordinary gelatin capsules. Prepare 1000 capsules.

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Abstract

The invention relates to a traditional Chinese medicine composite for antibiosis and antiphlogosis and preparation technology thereof. The traditional Chinese medicine composite is composed of three main drugs of active ingredient baicalin, active ingredient fibriuretinin, active ingredient berberine and pharmaceutically acceptable auxiliary material. The invention relates to a traditional Chinese medicine for antibiosis and antiphlogosis which has define and reliable curative effect, stable quality and safety and has no bacterial drug resistance, has efficacies of antibiosis and antiphlogosis, clearing heat and promoting diuresis and detoxication and invigorating the blood circulation and can be widely applied to treatment of disease caused by various bacterial infection.

Description

[0001] The application of the present invention is the application number "200710007803.X", the application date is January 11, 2007, the priority date is January 12, 2006, and the invention title is "An antibacterial and anti-inflammatory traditional Chinese medicine composition". Apply. field of invention [0002] The invention belongs to the field of traditional Chinese medicine, and relates to an antibacterial and anti-inflammatory traditional Chinese medicine composition, in particular to a Chinese medicinal composition composed of the active ingredient Scutellaria baicalensis or its active ingredient baicalin, the active ingredient Coptidis Rhizoma or its active ingredient berberine, the active ingredient Huangteng or its active ingredient Huanglian The traditional Chinese medicine composition composed of rattan can be used for treating respiratory tract infection, bacillary dysentery, gastroenteritis and the like. Background technique [0003] With the continuous emer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4375A61P31/04A61P31/06A61P29/00
Inventor 朱志宏
Owner HUNAN JIUDIAN PHARMA
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