Cefamandole nafate combined drug

A technology for cefamandole sodium and medicine, which is applied in the field of cefamandole sodium combination medicine, can solve the problems of unstable storage, drug thermal reaction, adverse reaction and the like, achieves complete sterilization, reduced pyrogen reaction, and drug quality high effect

Active Publication Date: 2010-09-08
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing cefamandole sodium injection is not stable when stored at room temperature, and there are drug allergies and adverse reactions to the gastrointestinal tract, liver, kidney, and blood system, as well as drug thermal reactions, intravenous infusion pain, and phlebitis. adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The cefamandole sodium combination medicine provided by the invention is made up of following medicinal composition weight ratio:

[0027] Cefamandole Sodium 500

[0028] Lidocaine 100

[0029] Reduced Glutathione 50

[0030] Monosodium Glutamate 200

[0031] Cefamandole sodium may be replaced by cefamandole, and the weight proportion is calculated by the weight of cefamandole sodium.

[0032] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0033] 1. With the water for injection of 50-200 times of the weight of cefamandole sodium under normal speed stirring, respectively cefamandole sodium, lidocaine, reduced glutathione, sodium glutamate are dissolved completely, prepare Obtain cefamandole sodium combined medicinal liquid;

[0034] 2. The cefamandole sodium composition medicinal liquid prepared in the first step is first subj...

Embodiment 2

[0049] The cefamandole sodium combination medicine provided by the invention is made up of following medicinal composition weight ratio:

[0050] Cefamandole Sodium 1500

[0051] Lidocaine 200

[0052] Reduced Glutathione 120

[0053] Monosodium Glutamate 500

[0054] Cefamandole sodium may be replaced by cefamandole, and the weight proportion is calculated by the weight of cefamandole sodium.

[0055] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0056] 1. With the water for injection of 50-200 times of the weight of cefamandole sodium under normal speed stirring, respectively cefamandole sodium, lidocaine, reduced glutathione, sodium glutamate are dissolved completely, prepare Obtain cefamandole sodium combined medicinal liquid;

[0057] 2. The cefamandole sodium composition medicinal liquid prepared in the first step is first su...

Embodiment 3

[0073] The cefamandole sodium combination medicine provided by the invention is made up of following medicinal composition weight ratio:

[0074] Cefamandole Sodium 1360

[0075] Lidocaine 180

[0076] Reduced Glutathione 110

[0077] Monosodium glutamate 350

[0078] Cefamandole sodium may be replaced by cefamandole, and the weight proportion is calculated by the weight of cefamandole sodium.

[0079] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0080] 1. With the water for injection of 50-200 times of the weight of cefamandole sodium under normal speed stirring, respectively cefamandole sodium, lidocaine, reduced glutathione, sodium glutamate are dissolved completely, prepare Obtain cefamandole sodium combined medicinal liquid;

[0081] 2. The cefamandole sodium composition medicinal liquid prepared in the first step is first su...

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PUM

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Abstract

The invention provides a cefamandole nafate combined drug, overcoming cefamandole nafate fever reaction, anaphylactic reaction, harm to liver, injection pain, phlebitis caused by injection and other untoward reactions in the prior art. The cefamandole nafate combined drug is safe to use, stable in quality and reliable in curative effect. The preparation process is energy-saving, environment-friendly and pollution-free.

Description

technical field [0001] The invention relates to cefamandole sodium combined medicine, its preparation process and application. Background technique [0002] Cefamandole sodium is a second-generation cephalosporin. The English name is Cefamandole Nafate, and the main ingredient is cefamandole sodium. It has a broad antibacterial spectrum, strong antibacterial effect, no absorption when taken orally, and good absorption when administered intravenously and intramuscularly. It is rapidly hydrolyzed into cefamandole in the body, and cefamandole is not metabolized in the body. The existing cefamandole sodium injection is not stable when stored at room temperature, and there are drug allergies and adverse reactions to the gastrointestinal tract, liver, kidney, and blood system, as well as drug thermal reactions, intravenous infusion pain, and phlebitis. Adverse reactions produced. Contents of the invention [0003] In order to overcome the defects in the preparation of cefama...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K47/18A61K47/42A61P31/16A61P11/00
Inventor 邓学峰蔡海德
Owner 邓学峰
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