Medicine composition for preventing and treating asthma

A composition and drug technology, applied in the field of drugs for respiratory diseases, can solve problems such as unsatisfactory adverse reactions, clinical effects and patient compliance, and aggravation

Inactive Publication Date: 2010-09-15
THE FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The data also shows that only about 70% of patients who inhale glucocorticoids according to the standard achieve clinical control (due to various reasons, in fact, most patients cannot standardize the medication for a long time, especially in primary medical institutions), and many of them stop taking th...

Method used

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  • Medicine composition for preventing and treating asthma

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Make inactivated Mycobacterium phlei into 0.3-0.8 μg / ml physiological saline injection (Utilines injection), salbutamol sulfate into 5mg / ml aqueous solution (or normal saline), and then follow the inactivated Live Mycobacterium phlei: Salbutamol sulfate is mixed in a weight ratio of 1:1000-2000, and the mixture is made into an aerosol for the patient to inhale, or jet atomized to the patient at an oxygen flow rate of 4-5L / min inhale.

Embodiment 2

[0017] Make inactivated Mycobacterium phlei into physiological saline injection (Utilines injection), the volume of each specification ampoule is 1ml, respectively 0.172μg (very low concentration), and it is made into salbutamol sulfate 5mg / ml aqueous solution (or normal saline), then according to inactivated Mycobacterium phlei: salbutamol sulfate is 1: 1000-2000 weight ratio mixes use, makes aerosol after mixing and inhales to patient.

Embodiment 3

[0019] The inactivated Mycobacterium phlei was made into physiological saline injection (Utilines injection), and the filling volume of each specification ampoule was 1ml, containing 4.6×10 bacteria. 6 ; 1.72μg, with salbutamol sulfate (mixed with 5mg / ml aqueous solution or saline), separately made into aerosol for patients to inhale.

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Abstract

The invention discloses a medicine composition for preventing and treating asthma, containing active components of 1 percent by weight of inactivated mycobacterium phlei F.U.36 and 1000-2000 percent by weight of salbutamol sulfate. The medicine composition is used for treating patients suffering from mild to moderate bronchial asthma and according with the 2006GINA diagnosis standard, measuring the lung function (FEV1%, PEF%) of the patients before and after treatment and the airway reactivity (PD20-FEV1), observing the symptoms of the patients and untoward effects of medicaments, and the like, and the difference of the FEV1% and the PEF% has no statistical significance as comparison before and after the treatment; the PD20-FEV1 after the treatment is obviously increased (p is smaller than 0.01) than that before the treatment; the provocation test negative conversion ratio is 88.9% (24 cases); and after the treatment, the symptoms of the patients are obviously relieved or disappear. Results show that the medicine composition can rapidly lower the airway reactivity and relieve the symptoms of asthma.

Description

technical field [0001] The invention relates to a medicine for treating respiratory diseases such as bronchitis and asthma, which comprises a combination of inactivated mycobacterium phlei and salbutamol sulfate active ingredients. Background technique [0002] Asthma is a common disease, frequently-occurring disease, and its incidence rate is on the rise. The Global Initiative for Asthma (GINA) clearly shows that there is currently no effective cure for bronchial asthma in the world, and the main treatment method is to achieve clinical control through long-term inhalation of glucocorticoids. The data also shows that only about 70% of patients who inhale glucocorticoids according to the standard achieve clinical control (due to various reasons, in fact, most patients cannot standardize the medication for a long time, especially in primary medical institutions), and many of them stop taking the drug. Often relapse or worsen afterwards. Due to the need for long-term medicati...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P11/06A61P11/00A61K31/137
Inventor 李超乾
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIV
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