Hydroxyapatite nanoparticle radionuclide marked product and preparation method thereof
A technology of hydroxyapatite and radionuclide, applied in the direction of radioactive carrier, can solve the problems of long degradation period, poor in vivo stability, label shedding, etc., to achieve the effect of strong penetrating power and stable labeling product
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[0024] The present invention will be further described in detail below in conjunction with specific experiments and analysis of their results and the corresponding accompanying drawings.
[0025] (1) Silane amination of hydroxyapatite nanoparticles
[0026] The hydroxyapatite nanoparticles were placed in an anhydrous ethanol solution, ultrasonicated at a frequency of 40KHz for 30min, washed repeatedly with anhydrous ethanol, and then set aside. In 90mL ethanol solvent, add 10mL aminopropyltriethoxysilane (molecular formula: (CH 3 CH 2 O) 3 SiCH 2 CH 2 CH 2 NH 2) of a diluted solution (coupling agent: ethanol = 1:5, V / V), sodium hydroxide solution was added dropwise to make the pH of the solution 8, and stirring was continued for 1 h at room temperature. Add 200mg of hydroxyapatite nanoparticles into the hydrolysis coupling agent solution, stir and react in a water bath at 50-60°C for 6 hours, after the reaction, place at room temperature for 2 days, filter, wash with et...
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