Chitosan nanoparticle with fluorescence labeling characteristic and method for preparing same
A chitosan nanometer and fluorescent labeling technology, which is applied in the directions of inactive medical preparations, fluorescence/phosphorescence, chemical instruments and methods, etc., can solve the problems of high cost, cumbersome synthesis process and low product yield, etc. The effect of low cost, simple preparation process and simple method
Inactive Publication Date: 2010-09-22
SHANGHAI JIAO TONG UNIV
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Problems solved by technology
However, in the existing technology, not only the synthesis process is cumbersome, the product yield is low, and the cost is high, but also some chemical solvents with relatively heavy pollution are used in the process, so the design and synthesis of various high-performance fluorescent labeling nanomaterials have encountered bottlenecks.
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Abstract
The invention relates to a chitosan nanoparticle with fluorescence labeling characteristic and a method for preparing the same, belonging to the technical field of the medicament. The chitosan nanoparticle has the following structural formula, wherein n is equal to 2, the mean size is 150-440 nm, and the thermal decomposition temperature is 194 DEG C. The method is easy and can be multi-functionally modified. The chitosan nanoparticle prepared with the method has medicinal fluorescence labeling characteristic and good biocompatibility.
Description
technical field The invention relates to a product and method in the technical field of medicine, in particular to a chitosan nanoparticle with fluorescent labeling properties and a preparation method thereof. Background technique The use of fluorescent markers for molecular recognition is a research hotspot in the field of life sciences in recent years. Fluorescent labeling technology refers to the use of some substances that can emit fluorescence to covalently bond or physically adsorb on a certain group of the molecule to be studied. Fluorescent properties to provide information about the object being studied. After the organic substance molecule absorbs light energy, the light emitted when the molecule transitions from the lowest vibrational energy level of the first singlet excited state to the ground state is called fluorescence. Utilize the change of its fluorescence characteristics after being adsorbed or covalently combined with the research object, so as to reflec...
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Login to View More IPC IPC(8): C08B37/08C09K11/06A61K47/36G01N21/64
Inventor 崔巍陆学民路庆华
Owner SHANGHAI JIAO TONG UNIV
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