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Micro-emulsion calcium preparation and preparation method as well as application thereof

A technology of microemulsions and preparations, which is applied in applications, food preparation, emulsion delivery, etc., can solve the problems of inability to co-dissolve and bioavailability of calcium agents, and achieve the effect of promoting calcium absorption and reducing the amount of excipients

Active Publication Date: 2013-01-30
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved by the present invention is to overcome the technical problem that calcium (water) and vitamin (oil) cannot be dissolved together in the existing calcium supplement preparation so that the bioavailability is low, and to provide a microemulsion calcium supplement preparation, the microemulsion The calcium supplement preparation utilizes the microemulsion structure to pack calcium preparation and vitamin components in a system. The calcium supplement preparation has a particle size of 10-100nm, and has the advantages of stable system properties, beautiful and transparent appearance, and high oral absorption and availability.

Method used

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  • Micro-emulsion calcium preparation and preparation method as well as application thereof

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Effect test

Embodiment 1

[0035] The preparation of embodiment 1 microemulsion calcium supplement preparation

[0036] Weigh each component according to the following weight: Tween-805g, soybean lecithin 0.5g, sorbitol 1g, ethanol 0.5g, vitamin AD 1g, calcium gluconate 10g;

[0037] Dissolve soybean lecithin in ethanol, slowly add Tween under stirring, and put in water bath at 40°C; add vitamin AD oil to the above mixture, put in water bath at 40°C, stir to obtain mixed liquid I, and set aside. Dissolve sorbitol and calcium gluconate in an appropriate amount of distilled water, heat appropriately (for example, 30-50° C.), and stir until clear to obtain a mixed solution II. Slowly add the mixed solution II into the mixed solution I, and stir to obtain a clear and transparent microemulsion calcium preparation.

[0038] The particle size of the prepared microemulsion calcium preparation measured by a Malvern laser particle size analyzer is 15.4nm.

Embodiment 2

[0039] The preparation of embodiment 2 microemulsion calcium supplement preparation

[0040] Weigh each component according to the following weight: Tween-80 20g, soybean lecithin 2g, sorbitol 10g, ethanol 2g, vitamin AD 10g, calcium gluconate 50g;

[0041] Dissolve soybean lecithin in ethanol, slowly add Tween under stirring, and put in water bath at 40°C; add vitamin AD oil to the above mixture, put in water bath at 40°C, stir to obtain mixed liquid I, and set aside. Dissolve sorbitol and calcium gluconate in an appropriate amount of distilled water, heat appropriately (for example, 30-50° C.), and stir until clear to obtain a mixed solution II. Slowly add the mixed solution II into the mixed solution I, and stir to obtain a clear and transparent microemulsion calcium preparation.

[0042] The particle size of the prepared microemulsion calcium preparation measured by a Malvern laser particle size analyzer is 11.8nm. The preparation of embodiment 3 microemulsion calcium su...

Embodiment 3

[0042] The particle size of the prepared microemulsion calcium preparation measured by a Malvern laser particle size analyzer is 11.8nm. The preparation of embodiment 3 microemulsion calcium supplement preparation

[0043] Weigh each component according to the following weight: Tween-80 10g, soybean lecithin 1.5g, sorbitol 6g, ethanol 1.0g, vitamin AD 5g, calcium gluconate 25g;

[0044] Dissolve soybean lecithin in ethanol, slowly add Tween under stirring, and put in water bath at 40°C; add vitamin AD oil to the above mixture, put in water bath at 40°C, stir to obtain mixed liquid I, and set aside. Dissolve sorbitol and calcium gluconate in an appropriate amount of distilled water, heat appropriately (for example, 30-50° C.), and stir until clear to obtain a mixed solution II. Slowly add the mixed solution II into the mixed solution I, and stir to obtain a clear and transparent microemulsion calcium preparation.

[0045] The particle size of the prepared microemulsion calcium ...

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Abstract

The invention discloses a micro-emulsion calcium preparation and a preparation method as well as application thereof. In the micro-emulsion calcium preparation, a micro-emulsion structure is used as a carrier of a calcium source, wherein the micro-emulsion structure is a homogeneous system which is composed of an oil phase, a water phase, surfactants and cosurfactants. In the invention, vitamin components are used as the oil phase of the micro-emulsion, lecithin and other components with the functions of reducing blood fat and the like are used as the surfactants of the micro-emulsion, and sorbitol and other components with the function of a flavoring agent are used as the cosurfactants of the micro-emulsion, so that on one hand, the calcium preparation and the vitamin components for promoting calcium absorption can be encapsulated in the same system, and vitamins exist in a liquid form, thereby furthest performing the function of the vitamins for promoting calcium absorption, and on the other hand, various components for forming the micro-emulsion structure are also used as the components for performing curative effect or functions of flavoring and the like, thereby reducing the usage amounts of auxiliary materials. The micro-emulsion calcium preparation of the invention has the advantages of stable system properties, beautiful and transparent appearance, high utilization degree of oral absorption, simple preparation process and the like.

Description

technical field [0001] The invention relates to a calcium supplement preparation, in particular to a microemulsion calcium preparation and its preparation method and application, belonging to the field of calcium supplement preparations. Background technique [0002] Calcium is an extremely important nutrient in the human body. It is the most important element that constitutes bones. It is especially important for the growth and consolidation of bones and teeth in developing children and adolescents. It is also important for the health of men and women of any age, especially women. Particularly important. The human body will lose 600 mg of calcium every day, and the main function of calcium is to maintain the normal operation of the nervous system, muscles, and heart, and it also has an impact on blood coagulation and blood pressure control. So it is very important to make sure you get enough calcium. [0003] The active form of vitamin D can induce a calcium-binding prote...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A23L1/304A23L33/16
Inventor 杜红冯前进牛欣
Owner SHANXI UNIV OF CHINESE MEDICINE
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