Method for preparing pinaverium bromide and intermediate compound of pinaverium bromide

Abstract

The invention discloses a method for preparing pinaverium bromide. In the method, a compound III undergoes an olefin reduction reaction to prepare the pinaverium bromide, namely, a compound IV. The invention also discloses a new compound, namely, an intermediate compound III of the pinaverium bromide. The invention provides a new method for synthesizing the pinaverium bromide and the intermediate of the pinaverium bromide. Due to the adoption of the method, the yield of the pinaverium bromide can be improved remarkably and the purity of the pinaverium bromide is enhanced to be over 99.8 percent.

Description

technical field The present invention relates to a kind of preparation method of pinaverium bromide, also relate to a kind of intermediate of pinaverium bromide. Background technique Pinaverium bromide, the chemical name is 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2(6,6-dimethylbicyclo[3 , 1,1] hept-2-yl) ethoxy] ethyl] morpholine bromide, developed by Solvay Pharmaceuticals, France, is a calcium antagonist with highly selective antispasmodic effects on the gastrointestinal tract, used for It has good effects in treating irritable bowel syndrome, pain related to intestinal dysfunction, abnormal bowel movements and discomfort, colon spasm, diarrhea, abdominal pain, peptic ulcer, pain related to biliary dysfunction, and gallbladder dyskinesia. It is considered to be an over-the-counter drug with good safety and a broad market prospect. The mechanism of action of pinaverium bromide on smooth muscle is the same as that of other calcium antagonists, but it has a highly se...

AI Technical Summary

Problems solved by technology

And the key intermediate 4-[2-[2(6,6-dimethylbicyclo[3,1,1]hept-2-yl)ethoxy]ethyl]morpholine has no specific literature report on its synthetic method

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