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Method for preparing bakuchiol

A technology of bakuchiol and psoralen, applied in the field of medicine, can solve the problems that the purification method has not been studied in depth and cannot be applied to industrialization

Inactive Publication Date: 2010-12-01
北京卓越同舟药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern studies have shown that bakuchiol is an important active ingredient in psoralen. Although silica gel column chromatography can be used in the prior art to make the purity of bakuchiol reach more than 90%, the method is a laboratory method and cannot Be applied to industrialization; Or adopt macroporous resin purification method, but follow-up purification method does not carry out in-depth research, therefore, can only obtain the bakuchiol of 50%-70% purity, so, research a kind of suitable for industrialized production, High-purity methods are imperative

Method used

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  • Method for preparing bakuchiol
  • Method for preparing bakuchiol

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Experimental program
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Effect test

Embodiment 1

[0026] Take psoralen, pulverize, extract with ethanol, recover ethanol, concentrate, add water to dissolve completely, let stand, filter, concentrate the filtrate, apply NKA macroporous adsorption resin, wash with water, remove the washing solution, elute with 30% ethanol, eluate Discarded, then eluted with 95% or absolute ethanol, recovered ethanol, concentrated, dried, and the dried product was extracted with organic solvent propanol, the extract was discarded, the residue was dried, washed with water, and dried to obtain bakuchiol.

Embodiment 2

[0028] Take psoralen, pulverize, extract with ethanol, recover ethanol, concentrate, add water to dissolve completely, let stand, filter, concentrate the filtrate, apply D101 macroporous adsorption resin, wash with water, remove the washing solution, elute with 90% ethanol, eluate Discarded, then eluted with 95% or absolute ethanol, recovered ethanol, concentrated, dried, and the dried product was extracted with organic solvent n-butanol, the extract was discarded, the residue was dried, washed with water, and dried to obtain bakuchiol.

Embodiment 3

[0030] Take psoralen, crush, extract with ethanol, recover ethanol, concentrate, add water to dissolve completely, let stand, filter, concentrate the filtrate, put on AB-8 macroporous adsorption resin, wash with water, remove the washing solution, elute with 35% ethanol, wash The liquid was removed and discarded, and then eluted with 95% or absolute ethanol, the ethanol was recovered, concentrated, dried, the dried product was extracted with organic solvent methanol, the extract was discarded, the residue was dried, washed with water, and dried to obtain bakuchiol.

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Abstract

The invention discloses a method for preparing a natural medicinal effective component, which is characterized by comprising the following steps of: extracting fructus psoraleae with ethanol; precipitating the extract with water; purifying filtrate by a macroporous resin; extracting the filtrate with an organic solvent; abandoning the extract; and washing residues. Technical method comparison experiments prove that the content of the bakuchiol prepared by the method is over 90 percent, which sufficiently proves the advancement of the method.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of bakuchiol. Background technique [0002] The traditional Chinese medicine Psoraleae is the fruit of the leguminous plant Psoralea corylifolia L. It is warm in nature, pungent in taste, and has the effect of invigorating the kidney and yang. Indications for cold diarrhea due to kidney deficiency, frequent urination, impotence, cold pain in the waist and knees, dyspnea due to deficiency and cold, and vitiligo for external use. Modern studies have shown that bakuchiol is an important active ingredient in psoralen. Although silica gel column chromatography can be used in the prior art to make the purity of bakuchiol reach more than 90%, the method is a laboratory method and cannot Be applied to industrialization; Or adopt macroporous resin purification method, but follow-up purification method does not carry out in-depth research, therefore, can only obtain ...

Claims

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Application Information

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IPC IPC(8): C07C39/19C07C37/68A61P15/10
Inventor 王爱民安晓雪周亚君
Owner 北京卓越同舟药物研究院有限公司
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