Application of B/E ring substituted silybin for preparing medicament for treating virus hepatitis B

A technology for viral hepatitis and milk thistle, applied in the field of medicine, can solve the problems of not being effectively developed, few documents, etc., and achieve the effects of being conducive to large-scale production, convenient source, energy saving and emission reduction, and large-scale production.
CN101919840BInactive Publication Date: 2012-12-05DALI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALI UNIV
Publication Date
2012-12-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to application of a B / E ring substituted silybin for preparing a medicament for treating virus hepatitis B, in particular to the application of a B ring ethoxy and E ring methoxy substituted silybin ester or medicinal salts thereof for preparing the medicament for eliminating hepatitis B virus surface antigens and hepatitis B e antigen and inhibiting HBV and DNA replication. The medicament has accurate activity of inhibiting HBsAg and HbeAg, and respective intensity of 18.5% and 23.0% in eliminating HBsAg and HbeAg at the concentration of 100 microgram / ml, which exceeds the positive control medicament of an alpha-interferon; and meanwhile, 23.3% inhibition ratio on HBV and DNA is displayed at the concentration of 100 microgram / ml; and therefore, flavonoid lignans or a medicinal salt thereof are proved to have the efficacy of inhibiting HbsAg, HbeAg, HBV and DNA. The application is predictably used for preparing the non-nucleoside medicament for eliminating HBsAg and HbeAg, inhibiting HBV and DNA replication and treating hepatitis B virus infectious diseases.
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Description

technical field

[0001] The present invention relates to the technical field of medicine, specifically, the present invention relates to a kind of silybin ester substituted by B ring ethoxy group and E ring methoxy group or its pharmaceutically acceptable salt is used for preparing and reducing hepatitis B virus surface antigen HBsAg and Use of hepatitis B e antigen HBeAg, inhibiting HBV DNA replication, and treating hepatitis B virus infection diseases. This flavonoid lignan has the definite activity of inhibiting HBsAg and HBeAg, and its intensity of removing HBsAg and HBeAg is respectively 18.5% and 23.0% at 100 micrograms / ml concentration, all exceeds positive control drug (10000 units / ml alpha-interference At the same time, it showed a 23.3% inhibitory rate to HBV DNA at this concentration. The above shows that the flavonoid lignan or its pharmaceutically acceptable salt has the effect of inhibiting HBsAg, HBeAg and HBV DNA; it can be expected to be used to prepare non-nu...

Claims

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