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Fukean dispersible tablet and preparation method thereof

A technology of dispersible tablets and dispersible tablets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant/algae/fungus/moss ingredients, etc., which can solve the problems of poor extraction effect of volatile oils, toxic side effects, loss of active ingredients of drugs, etc. problem, to achieve the effect of short disintegration time, fast dissolution rate and saving medicinal materials

Active Publication Date: 2010-12-22
江西亿友药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the main ingredients of this medicinal material for treating dysentery are volatile oils, the common processing methods are decoction and distillation. During decoction and distillation extraction, not only the extraction effect of volatile oils is poor, but a large amount of active ingredients of the medicine are lost, and a large amount of other ineffective ingredients are brought in. There are even ingredients that produce toxic side effects

Method used

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  • Fukean dispersible tablet and preparation method thereof
  • Fukean dispersible tablet and preparation method thereof
  • Fukean dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1, Fukean dispersible tablet

[0029] Agrimony 100g, Dijincao 125g, Twisted vine 1000g, Fotan mother 1000g, jiubing 670g, plantain 330g, pomegranate peel 330g, microcrystalline cellulose 90g, crospovidone 92g, magnesium stearate 2g , 120 grams of 95% concentration ethanol, 2 g of aspartame.

[0030] Preparation:

[0031] 1) Grind Agrimony into coarse powder, sieve, moisten with water for 2 hours, use carbon dioxide as extraction agent, under pressure of 20Mpa, perform supercritical extraction at 60°C for 45 minutes; Crushed in the machine into a mixed powder mainly of micron-sized particles with a particle size of 0.1 μm to 10 μm and nano-sized particles with a particle size of less than 0.1 μm;

[0032] 2) Next, decoct Twister, Huotanmu, Jiubing, Plantain, and pomegranate peel with water twice, each time for 2 hours, filter, and concentrate the filtrate to a relative density of 1.18-1.20 (85°C-90°C). ℃), add ethanol until the alcohol co...

Embodiment 2

[0042] Embodiment 2, the preparation of Fukean Dispersible Tablets

[0043] Agrimony 80g, Dijincao 95g, Twister vine 800g, Fotan mother 800g, Jiubing 536g, Plantain 264g, Pomegranate peel 264g, Low-substituted hydroxypropyl cellulose 85g, Lactose 88g, Micronized silica gel 1.5g, 75g gram 95% concentration ethanol, aspartame 1.6g.

[0044] Preparation:

[0045] 1) Pulverize Dijincao in an ultrafine pulverizer into a mixed powder mainly of micron-sized particles with a particle size of 0.1 μm to 10 μm and nano-sized particles with a particle size of less than 0.1 μm; then grind Agrimony into a coarse powder, and water Wet for 2 hours, use carbon dioxide as the extraction agent, under the pressure of 30Mpa, supercritical extraction, temperature 50°C, extraction for 60 minutes, extract Agrimony extract;

[0046] 2) Next, decoct Twister, Huotanmu, Jiubing, Plantain, and pomegranate peel with water twice, each time for 2 hours, filter, and concentrate the filtrate to a relative de...

Embodiment 3

[0056] Embodiment 3, the preparation of Fukean Dispersible Tablets

[0057] Agrimony 120g, Dijincao 150g, Twister vine 1200g, Fotan mother 1200g, Jiubing 804g, plantain 396g, pomegranate peel 396g, sodium carboxymethylcellulose 120g, mannitol 115g, talcum powder 4g, 130g 95% concentration ethanol, aspartame 3g.

[0058] Preparation:

[0059] 1) First, crush Agrimony into coarse powder, sieve, moisten with water for 1.5 hours, use carbon dioxide as extraction agent, under pressure of 15MpaMpa, perform supercritical extraction at 65°C for 30 minutes; Pulverize in the pulverizer into a mixed powder mainly of micron-sized particles with a particle size of 0.1 μm to 10 μm and nano-sized particles with a particle size of less than 0.1 μm;

[0060] 2) Next, decoct Twister, Huotanmu, Jiubing, Plantain, and pomegranate peel with water twice, each time for 2 hours, filter, and concentrate the filtrate to a relative density of 1.18-1.20 (85°C-90°C). ℃), add ethanol until the alcohol c...

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Abstract

The invention discloses a Fukean dispersible tablet and a preparation method thereof. The tablet is prepared from the main raw materials such as herba agrimoniae, herba euphorbiae humifusae, jasminum elongatum, Chinese knotweed herb, ovateleaf holly bark, plantain herb and pomegranate rind and the accessories such as a filling agent, a disintegrating agent, a lubricating agent, a wetting agent and a sweetening agent. The preparation method comprises the following steps: carrying out decocting and extracting, filtering the extract to recycle the ethanol, concentrating the ethanol into thick paste, drying the thick paste and grinding the thick paste into extract powder; and adding micropowder of herba euphorbiae humifusae, then adding the filling agent, the disintegrating agent and the sweetening agent to be mixed uniformly, then adding the wetting agent and supercritical extract of herba agrimoniae, carrying out wet granulation, adding the lubricating agent, pressing the mixture to prepare the dispersible tablet and coating the film to prepare the Fukean dispersible tablet. The dispersible tablet has the advantages of small dispersible grain size, short disintegrating time, quick dissolution, high bioavailability, adverse effects, etc. The dispersible tablet has good effect on treating abdominal pains, diarrhea and vomit caused by acute gastroenteritis and dyspepsia and especially has better effect on treating abdominal pains and diarrhea caused by bacillary dysentery.

Description

technical field [0001] The invention relates to a Fukean dispersible tablet for treating abdominal pain, diarrhea and vomiting and a preparation method thereof. Background technique [0002] Ordinary tablets of Fukean are sugar-coated tablets, which are easy to absorb moisture during storage, transportation and use, resulting in splits and unstable quality; after taking it, the disintegration time in the body is long (within 60 minutes), and the onset of action is slow . Dispersible tablets have the advantages of both oral tablets and oral liquid preparations, and the disintegration time is short (less than 3 minutes). [0003] In the course of clinical use, it was found that the original Fukean ordinary tablets had poor curative effect on abdominal pain and diarrhea caused by bacillary dysentery. It has a good curative effect on the treatment of abdominal pain and diarrhea, especially the treatment of diarrhea and abdominal pain caused by bacillary dysentery. [0004] Di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/28A61P1/12A61P31/04
CPCY02A50/30
Inventor 张嵩
Owner 江西亿友药业有限公司
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