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Use of silicon dioxide mesoporous material in preparation of antidote for treating heavy metal poisoning

A technology of silica and mesoporous materials, applied in drug combinations, anti-toxic agents, pharmaceutical formulations, etc., can solve the problems of unbalanced distribution of heavy metals, low relative concentration, lack of long-term action mechanism, etc., and achieve small toxic and side effects , Detoxification of heavy metal poisoning, high efficiency effect

Inactive Publication Date: 2011-12-21
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it lacks a long-term mechanism of action for health-damaging conditions such as chronic poisoning or sub-poisoning. The mechanism of action of existing oral drugs is to be absorbed by the intestinal tract into the circulatory system, and then compete for the lead ions in the blood to form a complex. and then be metabolized out of the body, so the existing detoxifying metal complexing agents have the following defects: firstly, they participate in the circulation of the whole body, and have large toxic and side effects; secondly, the distribution of heavy metals in the human body is very unbalanced. Yes, the concentration of heavy metal ions such as lead in the blood is only a form of its existence in the human body, and its relative concentration is not very high. Therefore, the detoxification efficiency of the existing special detoxification metal complexing agent is still not high, and long-term repeated medication is required.

Method used

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  • Use of silicon dioxide mesoporous material in preparation of antidote for treating heavy metal poisoning
  • Use of silicon dioxide mesoporous material in preparation of antidote for treating heavy metal poisoning
  • Use of silicon dioxide mesoporous material in preparation of antidote for treating heavy metal poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Add 2.0g of CTAB to 270ml of deionized water and 205ml of ammonia solution, ultrasonically disperse, the solution becomes clear when heated and stirred, then slowly add 10ml of TEOS dropwise, react at room temperature for 2-3 hours, and filter to obtain intermediate product A;

example 2

[0061] Disperse 2.7g of F127 in a mixed aqueous solution of 15mL of concentrated hydrochloric acid and 110ml of deionized water, stir in a water bath at 32°C for 3h, then add 9.1ml of TEOS dropwise, continue to stir for 10min, let stand and age for 20h, and filter to obtain intermediate product A ;

Embodiment 3

[0063] Disperse 2.0g of P123 in 45ml of deionized water and 28ml of 4mol / L HCl mixed solution, stir and react in a water bath at 40°C for 1 hour, then add 4.76ml of TEOS dropwise, continue stirring and reacting in a water bath at 40°C for 1 day, filter and dry Intermediate product A can be obtained;

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Abstract

The invention discloses the use of a silicon dioxide mesoporous material in the preparation of an antidote for treating heavy metal poisoning, and provides the use of a new medicament for stopping enterohepatic circulation for treating heavy metal poisoning. The silicon dioxide material has a mesoporous structure; the internal and external surfaces of the mesopores are modified and connected withfunctional groups having sulfydryls; and the silicon dioxide mesoporous material is prepared into the antidote for absorbing heavy metals in the gastrointestinal tract.

Description

Technical field: [0001] The invention relates to a medical application of silicon dioxide material in the preparation of detoxification medicine for heavy metal poisoning. Background technique: [0002] With the development of modern industry, the pollution of the environment is also increasing, and the number of patients with heavy metal poisoning is also increasing. The main toxicological mechanism of heavy metal poisoning is that heavy metals or their compounds competitively bind to proteins containing sulfhydryl groups. Some important enzyme proteins As a result, the activity of the drug is inhibited, and normal physiological activities fail, leading to symptoms of poisoning and even death. [0003] The liver is the detoxification organ of the human body. Most of the toxic substances are concentrated in the middle of the liver. For example, the concentration of lead ions in the bile of patients with lead poisoning is 400-600 times higher than that in the blood. After th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/04A61K33/00A61K47/02A61P39/02
Inventor 徐慧张鹏华程泽能常胜利
Owner CENT SOUTH UNIV
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