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Method for carrying out full quality control on Chinese patent drugs by using mixed contrast

A technology of mixed control and Chinese patent medicine, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult promotion and poor reproducibility, and achieve the effects of saving inspection time and cost, easy promotion and application, and large amount of chromatographic information

Inactive Publication Date: 2011-01-05
河北省药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at this stage, the research on fingerprints is in its infancy. The main research is on the fingerprints of relatively simple injections. Poor reproducibility, difficult to popularize, some common Chinese patent medicines cannot use fingerprints to control quality

Method used

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  • Method for carrying out full quality control on Chinese patent drugs by using mixed contrast
  • Method for carrying out full quality control on Chinese patent drugs by using mixed contrast
  • Method for carrying out full quality control on Chinese patent drugs by using mixed contrast

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 (using gas chromatography-mass spectrometry to identify each medicinal taste in Guanxin Suhe Pills):

[0029] Guanxin Suhe Pills are composed of borneol, frankincense, sandalwood, styrax, and inulin. It has the effects of regulating qi, widening the chest, and relieving pain. It is clinically used for the treatment of angina pectoris, chest tightness, and shortness of breath.

[0030] (1) Main instruments: gas chromatography mass spectrometry (Shimadzu 2010Plus, Japan), balance (Metters AE-163, Switzerland).

[0031] (2) Materials and reagents: borneol, frankincense, sandalwood, styrax, and inulin as reference medicinal materials (National Inspection Institute, batch number: 110743-200504, 120970-200604, 121240-200402, 120931-200202, 121090-200602).

[0032] The test product Guanxin Suhe Pill was purchased from a pharmacy.

[0033] Water is pure water, and other reagents are analytically pure.

[0034] (3) Chromatographic conditions: Chromatographic colum...

Embodiment 2

[0044] Example 2: Using high performance liquid chromatography to identify the flavors of each medicine in Zhisou Dingchuan Pills.

[0045] Zhisou Dingchuan Pill is composed of ephedra, bitter almond, licorice, and gypsum. It has the effect of cooling the lungs and relieving asthma. It is mainly used for external cold and internal heat, body heat and thirst, cough with phlegm, and asthma. The treatment of shortness of breath, chest and diaphragm fullness, and acute bronchitis. The gypsum in this prescription is a mineral medicine and has no chromatographic behavior, so its quality control is carried out by microscopic identification, and the quality control of other three herbs such as ephedra, bitter almond, and licorice is carried out by high performance liquid chromatography.

[0046] (1) Main instruments

[0047] High performance liquid chromatography (Shimadzu 20A, Japan), balance (Metters AE-163, Switzerland).

[0048] (2) Materials and reagents

[0049] Ephedra, bitt...

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Abstract

The invention relates to a method for identifying on Chinese patent drugs by using mixed contrast, which comprises the steps of: 1, obtaining a supply sample chromatogram map; 2, obtaining a mixed contrast chromatogram map; and 3, comparing whether retention times of chromatographic peaks in the supply sample chromatogram map and the mixed contrast chromatogram map are consistent or not. The invention has the advantages of identifying drug tastes of the Chinese patent drugs by using a supply sample contrast mode under the same chromatogram condition, overcoming the bottleneck problem of identifying the drugs only by the conventional Chinese patent drug quality standard, controlling the integral quality of the drugs, and greatly saving detection time and cost.

Description

technical field [0001] The invention relates to a method for comprehensive quality control of Chinese patent medicines by using a mixed control. Background technique [0002] The quality evaluation of traditional Chinese medicine has always been a difficult problem to solve. Since ancient times, there has been a saying that "pills and ointments are hard to distinguish from gods". From the founding of New China to the present, the quality of traditional Chinese medicine has also realized the transition from process experience control to post-inspection control . In recent years, with the continuous advancement of modern chemical analysis technology, there are more and more research methods and methods for the internal chemical components of Chinese patent medicines. The known internal components and their determination methods are used for quality control, and corresponding inspection standards are formulated. Great progress has been made. For example, the Chinese medicinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 冯丽刘永利王熳李冬梅袁浩
Owner 河北省药品检验所
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