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Method for extracting alkannin naphthoquinone pigment

A technology for naphthoquinones and comfrey, which is applied in the field of extracting naphthoquinone pigments from shikonin, can solve the problems of complicated operation, residual organic solvent, and high extraction cost, and achieves high product quality, natural quality, and high extraction rate. Effect

Inactive Publication Date: 2011-01-12
XINJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods all have problems such as high extraction cost, residual organic solvents and cumbersome operation steps in the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Put 10kg of Xinjiang soft comfrey into the extraction kettle of the 24L subcritical fluid extraction process after pulverization, use 1,1,1,2-tetrafluoroethane (R134a) as the extraction agent, the extraction temperature is controlled at 45 ° C, the pressure It is 3.0MPa; the separation temperature is 55°C, the separation pressure is 0.1MPa; the extraction time is 3h. After the extraction was finished, the solvent R134a was recovered, and 676g of crude shkonadhiquinone pigment extract was obtained from the separator.

Embodiment 2

[0022] Send 676g of comfrey extract obtained in the above steps into the film evaporator of molecular distillation uniformly at a rate of 3mL / min using a material pump, heat through the jacket, control the distillation temperature at 60°C, and control the vacuum degree at 30Pa In between, dehydration and desolventization were carried out under the condition that the condensation temperature was 20°C, and 615.8 g of shikonadhoquinone pigment extract was obtained. After analysis, the main several naphthoquinone pigments in this extract were shikonin, Deoxyshikonin, acetylshikonin, dimethylacrylshikonin, isovalerylshikonin, (2-methyl n-butyryl) shikonin, isobutyryl shikonin, etc., naphthoquinone The total content of total pigments is 48.5%.

Embodiment 3

[0024]Take 250 g of the shkonadhiquinone pigment extract obtained in the above-mentioned Example 2 and send it into the distiller of molecular distillation through a delivery pump at a flow rate of 3 mL / min. The distillation temperature is controlled at 90° C., and the vacuum degree is controlled between 3 Pa. Molecular distillation was carried out under the condition that the condensation temperature was 20° C., and the distillate was sent into the product collection tank by the discharge pump to obtain 75.3 g of refined product I. After analysis, the contents of shikonin, deoxyshikonin and acetylshikonin were respectively increased by 58.7%, 43.2%, and 42.1% compared with the directly obtained shikonin extract. The content of valeryl shikonin, (2-methyl n-butyryl) shikonin, isobutyryl shikonin etc. increased by about 10%.

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PUM

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Abstract

The invention discloses a method for extracting an alkannin naphthoquinone pigment extract and series products thereof by combining subcritical 1,1,1,2-tetrafluoroethane (R134a) extraction and molecular distillation technology. The method has the characteristics of high extraction rate, low extraction temperature, short production cycle, high product quality, low production cost and the like; andthe prepared alkannin naphthoquinone pigment extract and the refined alkannin naphthoquinone derivative series products can be used for pharmaceutical industry, food industry, cosmetics industry, printing and dyeing coloring agents and the like.

Description

technical field [0001] The invention relates to a method for extracting shikonaquinone pigments. More specifically, the present invention relates to a method for extracting shikonaquinone pigment extract and its series products by combining subcritical 1,1,1,2-tetrafluoroethane (R134a) and molecular distillation technology. Background technique [0002] Comfrey, a plant in the family Boraginaceae, is commonly used in traditional Chinese medicine and is named for its purple root. Included in the Chinese Pharmacopoeia, there are mainly three types of medicinal plants of the Boraginaceae family: soft comfrey, hard comfrey and Yunnan comfrey. Soft comfrey, also known as Xinjiang comfrey, scientific name Arnebia euchroma (Royle) Johnst, is a perennial herb of the family Boraginaceae endemic to Xinjiang. It mainly grows in the grass on the sunny slopes of the Tianshan Mountains. It is the best quality of medicinal comfrey. The species with the highest content of naphthoquinones....

Claims

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Application Information

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IPC IPC(8): C09B61/00C09B67/10C09B67/54
Inventor 刘玉梅刘奎钫
Owner XINJIANG UNIVERSITY
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