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Anti-ofloxacin monoclonal antibody and immunoassay method of ofloxacin using the same

An immunoassay, antibody technology, applied in the direction of immunoglobulins, specific peptides, measuring devices, etc.

Inactive Publication Date: 2011-01-12
SEKISUI MEDICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is not possible to accurately detect only levofloxacin that retains antibiotic activity

Method used

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  • Anti-ofloxacin monoclonal antibody and immunoassay method of ofloxacin using the same
  • Anti-ofloxacin monoclonal antibody and immunoassay method of ofloxacin using the same
  • Anti-ofloxacin monoclonal antibody and immunoassay method of ofloxacin using the same

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Abstract

It is intended to provide a method of accurately and simply detecting a compound represented by the formula (I) in a human sample. For producing an antibody which recognizes a compound represented by the formula (I) and shows no cross-reaction with metabolites thereof, an N-oxide form of the compound represented by the formula (I) and desmethyl-levofloxacin, an antigen obtained by attaching bovine serum albumin to the carboxy group at position 6 of the compound represented by the formula (I) was used. Further, for constructing an immunoassay method for measuring the unmetabolized compound represented by the formula (I), the antibody was used.

Description

technical field The present invention relates to antibodies that react with ofloxacin (ie, an antibiotic compound) and the various optical isomers that form ofloxacin, but do not react with its primary metabolite. Background technique New quinolone antibiotics are those that exhibit significantly improved antibiotic spectrum and antibiotic activity compared to pyridonecarboxylic acid (pyridonecarboxylic acid) antibiotics (e.g., enoxacin and norfloxacin), and Drugs that exhibit highly selective toxicity by inhibiting bacterial DNA gyrase. Ofloxacin, levofloxacin, norfloxacin, ciprofloxacin, etc. have been clinically used to treat various infections, suppurative diseases, etc., and have obtained excellent therapeutic effects. Ofloxacin is represented by the following chemical formula (I), and has one asymmetric carbon atom in the chemical structure. Ofloxacin is a racemate comprising two optically active substances (ie, S-(-)-isomer and R-(+)-isomer) in a composition ratio ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/44C07K14/76C07K14/79C12N5/10C12N15/02G01N33/50G01N33/53G01N33/577C12P21/08
CPCC07K2317/33G01N33/9446C07K16/44A61P31/00
Inventor 宫崎修田久保耕平深町勇日下绘里子柏木美惠子
Owner SEKISUI MEDICAL CO LTD
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