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Method for checking the state of a pipette, pipetting method, pipetting device, and suction tube for a pipetting device

A technology for pipettes and suction tubes, which is applied in mechanical equipment, measuring tubes/pipettes, chemical instruments and methods, etc., can solve problems such as high cost and achieve the effect of low cost

Inactive Publication Date: 2011-01-19
BECKMAN COULTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With disposable tips corresponding to special designs (Ausgestaltung), e.g. tips configured to conduct electricity or with special electrodes, high costs can be incurred

Method used

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  • Method for checking the state of a pipette, pipetting method, pipetting device, and suction tube for a pipetting device
  • Method for checking the state of a pipette, pipetting method, pipetting device, and suction tube for a pipetting device
  • Method for checking the state of a pipette, pipetting method, pipetting device, and suction tube for a pipetting device

Examples

Experimental program
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Embodiment Construction

[0053] figure 1 The lower end of the pipette 10 with the pipette tip 14 is shown. The pipette tip has a collar 16 via which the pipette tip 14 is mounted on the aspiration tube 12 . The pipette tip 14 is made, for example, of polypropylene.

[0054] The suction tube 12, only partially depicted, can be used in a fully automated robotic system for pipetting. A suction piston is located in the suction tube 12 in a known manner, which can be driven by a motor shaft to draw liquid into or out of the pipette.

[0055] In other embodiments, the piston is located in an external device that is connected to the suction tube by a hose. Optionally, a suction device, such as a corresponding pump, can also be connected to the suction line.

[0056] Reference numeral 18 denotes a piezoelectric actuator serving as an ultrasonic generator and an ultrasonic receiver. It is advantageous to use elements made of piezoelectric materials, such as lead zirconate titanate ceramics. The piezoelec...

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Abstract

The invention relates to a method for checking the state of a pipette comprising a suction tube and a pipette tip. According to the invention, an ultrasound is coupled into the wall of the suction tube, and the damping of the ultrasound signal is measured as a function of frequency. By comparing the measured frequency-dependent damping to at least one reference measurement or a calibration curve based on reference measurements, it is determined whether the pipette is in a functional condition, and / or whether the pipette contains or contacts fluid. The invention further relates to a pipetting method using the method for checking a pipette state according to the invention, a suction tube arrangement for a pipetting device for pipetting fluid, and a pipetting device that can be used to perform the methods according to the invention.

Description

technical field [0001] The present invention relates to a method for detecting the state of a pipette including a suction tube and a pipette tip, a pipetting method using this method, a pipetting device and a suction tube for a pipetting device, by which Pipetting devices and suction tubes enable these methods. Background technique [0002] For example, in analytical chemistry it is often necessary to dispense very small quantities of liquid with high precision, for which pipettes are usually used. Even in automated pipetting methods, it is important to know exactly the state of the pipette, especially the exact working capacity or fill volume. In addition to this, it is advantageous to know the point in time at which the pipette touches the surface of the liquid during the approach to the liquid. [0003] According to the method described in US 5,428,997, the pin-like end of the sonotrode is immersed in the liquid. Observe the ultrasonic resonance frequency in order to o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01F23/296B01L3/02G01N29/11G01N35/10
CPCG01N2035/1025G01F23/2965B01L2200/0605G01N35/1011G01N29/245B01L2400/0439G01N29/30B01L2200/143B01L3/0275G01N29/032
Inventor 马蒂亚斯·瓦塞麦尔策诺·冯·古藤贝格弗里多·勒斯
Owner BECKMAN COULTER INC
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