Preparation process of troxerutin injection

Abstract

The invention relates to a preparation process (preparation method) of a troxerutin injection, overcoming the defect of traditional preparation process of the troxerutin injection and providing a preparation process with low cost, high yield and more stable quality of finished products. The preparation process comprises the following steps of: 1, calculating the usage amount of raw materials according to 100% of the labeled amount, opening an injecting water valve of a concentrated solution tank, putting fresh injection water about 40% of preparing amount, opening a stirring device, adding sodium citrate, slowly adding the raw materials into the concentrated solution tank after the sodium citrate is completely solved, and stirring to fully dissolve; (2), regulating a pH value of the liquor to 6.3-6.4 by 10% sodium citrate solution; (3) adding medicinal carbon to a medicinal solution and boiling for 30min, removing carbon from the medicinal solution and filtering the medicinal solution in a dilute solution tank, adding the injection water to the preparing amount, filtering the solution by 0.45 microns and 0.22 microns cylinder type filters (carrying out a bubbling point test before and after the usage) till visible foreign bodies are qualified, and encapsulating the qualified semi-finished products. The product prepared by the preparation process has the advantages of reduced rate of waste products, high yield, good stability of product quality, and the like, is beneficial to mass production and convenient for storage and market sale, has good market prospect and is worthy of promotion.

Description

1. Technical field [0001] The invention relates to a preparation process of injections, in particular to a new preparation process of troxerutin injection which is superior to the traditional process. 2. Background technology [0002] Troxerutin injection can inhibit the aggregation of platelets and prevent thrombosis. It is mainly used clinically for ischemic cerebrovascular diseases (such as cerebral thrombosis and cerebral embolism), thrombophlebitis, central retinitis, vascular For diseases such as edema caused by increased permeability, the market demand for this product is relatively large. [0003] There are several domestic enterprises producing it, and the production process adopted is the traditional preparation process: calculate the amount of raw materials used according to 100% of the labeled amount, put fresh water for injection of about 40% of the prepared amount into the concentrated preparation tank, turn on the agitator, and add wolfberry in turn Stir the ...

AI Technical Summary

Problems solved by technology

Due to the poor clarity, high reject rate and high production cost of the product liquid medicine produced according to the traditional process, the content of the product within the validity period is greatly reduced, and the market sales and clinical medication are greatly affected.

Images