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Medicinal composition for preventing and treating diabetic complications and preparation method thereof

A composition and complication technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of no diabetic neuropathy, unsatisfactory effect, etc., to improve the utilization rate of medicinal materials, reduce volume and take Dosage, effect of concentration of effective medicinal ingredients

Active Publication Date: 2012-06-27
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, diabetic neuropathy is a frequently-occurring and common disease, accounting for 47-91% of diabetic patients. Medical practice shows that the effect of simple chemical drug treatment is not satisfactory. At present, there is no effective drug specifically for diabetic neuropathy.

Method used

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  • Medicinal composition for preventing and treating diabetic complications and preparation method thereof
  • Medicinal composition for preventing and treating diabetic complications and preparation method thereof
  • Medicinal composition for preventing and treating diabetic complications and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 soft capsule medicine of the present invention

[0017] Salvia miltiorrhiza 50kg, pulverized, extracted by percolation with 90% ethanol, the ethanol solution was decompressed to recover ethanol, concentrated, allowed to stand for precipitation, and the precipitate was separated, and the mother liquor was set aside. An appropriate amount of 8% sodium carbonate solution was added to the precipitate, fully stirred, filtered, washed with water, and dried to obtain the total tanshinone extract, wherein the weight content of the total tanshinone was 51.9%.

[0018] The above-mentioned 90% ethanol percolation of Danshen medicinal residues is then extracted with 50% ethanol percolation, the percolation liquid is decompressed and recovered to remove ethanol, the aqueous solution is combined with the above mother liquor, and 100 liters of HPD-100 macroporous resin column is installed, and the Wash with 200 liters of water to remove impurities, then elute with 300 lit...

Embodiment 2

[0021] Embodiment 2 pill medicine of the present invention

[0022] Take 50 kg of Salvia miltiorrhiza, crush it into a coarse powder, extract it by percolation with 80% ethanol, recover ethanol from the ethanol solution under reduced pressure, concentrate, let it stand for precipitation, separate the precipitate, and use the mother liquor for later use. The precipitate is washed with an appropriate amount of water and dried under reduced pressure to obtain a total tanshinone extract, wherein the weight content of the total tanshinone is 26.8%.

[0023] The above-mentioned 80% ethanol percolated Danshen medicine dregs were extracted by percolating with 80°C hot water, the aqueous solution (percolation liquid) was combined with the above mother liquor, and the pH value was adjusted to 2.0 with hydrochloric acid, and passed through 100 liters of HPD-100 large Porous resin column, washed with 100 liters of acid water with a pH value of 2.0 to remove impurities, then eluted with 40...

Embodiment 3

[0026] Embodiment 3 tablet medicine of the present invention

[0027] Take 50kg of Salvia miltiorrhiza, crush it into a coarse powder, extract twice with 70% ethanol under reflux, combine the ethanol extracts, recover ethanol under reduced pressure, concentrate, let it stand for precipitation, separate the precipitate, and dry to obtain the total tanshinone extract, wherein the total tanshinone The weight content is 20.3%, and the precipitation mother liquor is for subsequent use.

[0028] The Danshen dregs extracted with 70% ethanol were added 9 times and 7 times with water respectively, extracted twice at 60°C with dynamic stirring and warm soaking, filtered, the filtrate was combined with the above mother liquor, and the pH value was adjusted to 2.0 with hydrochloric acid. HPD-100 macroporous resin column, washed with 200 liters of water to remove impurities, then eluted with 300 liters of 70% v / v ethanol, collected the ethanol eluate, recovered ethanol under reduced pressu...

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Abstract

The invention relates to a medicinal composition for preventing and treating diabetic complications and a preparation method thereof. The medicinal composition comprises the following active ingredients in part by weight: 3 parts of total phenolic acids of root of red-rooted salvia, 0.2 to 1.5 parts of total tanshinones and 1 to 10 parts of total flavonoids of kudzuvine root, and pharmaceuticallyacceptable auxiliary materials or carriers. The preparation method comprises the following steps of: respectively extracting corresponding active ingredients from medicinal materials, namely the rootof red-rooted salvia and the kudzuvine root; and mixing the active ingredients and the pharmaceutically acceptable auxiliary materials or carriers according to the proportion to prepare a corresponding medicinal preparation. Deep studies prove that due to the compatibility of the total tanshinones in the root of red-rooted salvia, the total flavonoids of the kudzuvine root and the total phenolic acids of the root of red-rooted salvia, the medicinal composition has obvious synergistic effect, achieves unexpected obvious effect, enhances the medicinal effect of the composition of the total flavonoids of the kudzuvine root and the total phenolic acids of the root of red-rooted salvia and improves the utilization rate of the medicinal materials.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating diabetic complications, especially suitable for but not limited to preventing and treating diabetic neuropathy. Background technique [0002] Diabetes is a common and multiple disease, and its harm to human health is mainly manifested in a variety of chronic complications, including diabetic nephropathy, diabetic eye disease, diabetic heart disease, diabetic neuropathy and other microvascular diseases, etc. . Among them, diabetic neuropathy is a frequently-occurring and common disease, accounting for 47-91% of diabetic patients. Medical practice shows that the effect of simple chemical drug treatment is not satisfactory. Currently, there is no effective drug specifically for diabetic neuropathy. Chinese Patent Publication No. CN1985886A (200510111991) discloses a pharmaceutical composition for treating diabetes consisting of total flavonoids of Pueraria lobata root and s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P3/10A61P25/02A61K31/58
Inventor 易进海谭正怀刘云华熊静悦黄志芳刘玉红陈燕刘倩伶
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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