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Adhesive complex coacervates and methods of making and using thereof

A technology of adhesive compounding and agglomeration, which is applied in the directions of chemical instruments and methods, adhesive types, detergent compositions, etc., can solve the problem of unsatisfactory stable reduction of small joint fragments, fragile CP cement, low mechanical strength, etc. question

Inactive Publication Date: 2011-02-16
UNIV OF UTAH RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main disadvantage is that the CP cement is brittle, has low mechanical strength, and thus is not ideal for stable reduction of facet joint fragments

Method used

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  • Adhesive complex coacervates and methods of making and using thereof
  • Adhesive complex coacervates and methods of making and using thereof
  • Adhesive complex coacervates and methods of making and using thereof

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Embodiment

[0075] The following examples are set forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how the compounds, compositions and methods described and claimed herein were made and evaluated, and are intended to be purely illustrative and not limiting scope of the inventor's invention. Efforts have been made to ensure accuracy with respect to numbers (eg, amounts, temperature, etc.), but certain errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in °C or is at room temperature, and pressure is at or near atmospheric. There are numerous variables and combinations of reaction conditions, such as component concentrations, desired solvents, solvent mixtures, temperatures, pressures, and other reaction ranges and conditions that can be used to optimize the product purity and yield obtained from the described process. Such treatment conditions can be optimized by requir...

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Abstract

Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more poly anions, and one of more multivalent cations. The polycations and polyanions in the adhesice complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared with conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application Serial No. 61 / 023,173, filed January 24,2008. This application is hereby incorporated by reference in its entirety for all of its teachings. Background of the invention [0003] Fractures are a serious health problem in today's society. In addition to fractures themselves, numerous other health risks are also associated with fractures. For example, an intra-articular fracture is a bone injury that extends to the articular surface and fragments the cartilage surface. Fractures of cartilaginous surfaces often result in debilitating post-traumatic arthritis. It is believed that the major determinants in the development of post-traumatic arthritis are the energy applied at the time of the injury, the patient's genetic predisposition (or lack thereof) for post-traumatic arthritis, and the precision and maintenance of reduction. Of the 3 prognostic factors, the...

Claims

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Application Information

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IPC IPC(8): C11D17/00
CPCA61L2300/602C08F8/00A61L2300/62C08F8/06A61L27/54A61L24/043A61L24/0015A61L27/26C09J133/14A61L2300/412C08F8/10C08F2800/10C08F2810/20C08F2810/30C08F230/02
Inventor R·J·斯图尔特H·邵
Owner UNIV OF UTAH RES FOUND
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