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Use of triphosadenine and derivative thereof in preparation of antidepressant and/or antianxietic medicaments

An adenosine triphosphate derivative and a technology of adenosine triphosphate, which are applied in the field of adenosine triphosphate and its derivatives, can solve the problems of high price, slow onset of action, difficult identification and the like, and achieve the effects of low price, small toxic and side effects, and long-lasting effect

Inactive Publication Date: 2011-04-06
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

The treatment of depression mainly relies on drug therapy; there are many effective drugs for the treatment of depression in clinical practice, but they still cannot meet the needs of treatment
What is especially important is that there are some common problems in current antidepressants: 1. The onset is slow, and the clinical symptoms can only be improved after taking the medicine for 3-6 weeks, and long-term medication is needed to cure; it is difficult for the patient to persist until the medicine starts to work. This is the main reason why the clinical effect of depression treatment is poor at present.
2. There are many side effects; 3. It is expensive; 4. At least 35% of patients with depression do not respond to current drug treatment
[0004] Although anxiety and depression are medically divided into two mental illnesses, they often coexist clinically and are sometimes difficult to distinguish. Therefore, many scholars suggest that the two be combined for treatment

Method used

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  • Use of triphosadenine and derivative thereof in preparation of antidepressant and/or antianxietic medicaments
  • Use of triphosadenine and derivative thereof in preparation of antidepressant and/or antianxietic medicaments
  • Use of triphosadenine and derivative thereof in preparation of antidepressant and/or antianxietic medicaments

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Embodiment 1

[0036]Experimental Study on the Drug Efficacy and Pharmacological Effects of Adenosine Triphosphate on Antidepressant and Anxiety

[0037] 1. Forced swimming test (FST): Porsolt et al. proposed the forced swimming model in 1977, and found that different drugs have different changes in the immobility time of forced swimming in the FST test. Antidepressants can effectively reduce the immobility time. Models are one of the most commonly used methods for screening antidepressants. The specific steps are: put the mice individually into an open transparent glass jar (the jar height is 45 cm, the diameter is 19 cm, and the water temperature is 23-25°C) to swim freely for 6 minutes, measure and calculate the immobility of the mice within 4 minutes ( Immobility) as an indicator of the antidepressant effect of the drug. The standard for the mice not to swim is that the experimental mice are slightly curled up, in a floating state, and their nostrils are exposed to the water. Potent an...

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Abstract

The invention provides the use of triphosadenine and derivative thereof in the preparation of antidepressant and / or antianxietic medicaments. The prepared medicaments are quick in effectiveness and good in effect and have fewer side effects and long lasting action.

Description

technical field [0001] The present invention relates to the use of adenosine triphosphate and derivatives thereof, in particular to the use of adenosine triphosphate and derivatives thereof in preparing antidepressant and / or anxiolytic drugs. Background technique [0002] Depression seriously endangers human life and health. Depression refers to a type of mood disorder syndrome characterized by depressed mood, slow thinking, accompanied by psychomotor retardation symptoms such as decreased interest and decreased initiative. The incidence rate is very high, about 15-17%, and it has been increasing year by year in recent years; according to the World Health Organization, by 2020, depression will become the first cause of disability and the main killer of human beings in the 21st century (Murray ,1997). It can be seen that depression has caused a huge burden on society, family and patients themselves, and seriously endangered human life and health. Therefore, the prevention ...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P25/24A61P25/22
Inventor 朱心红曹雄高天明孙丽荣李亮萍李树基李晓文方莹莹
Owner SOUTHERN MEDICAL UNIVERSITY
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