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Compositions comprising galactomannan and a process thereof

A composition and compound technology, applied in the field of new plant-derived compounds, can solve the problem of no data on the curative effect of galactomannan

Active Publication Date: 2011-04-13
INDUS BIOTECH PVT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are no data on the efficacy of galactomannan independent of trigonelline and amino acids

Method used

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  • Compositions comprising galactomannan and a process thereof
  • Compositions comprising galactomannan and a process thereof
  • Compositions comprising galactomannan and a process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] 1000 g of fenugreek seeds with a moisture content below 7% were crushed in a roller flaker to a thickness of 5 mm. The crushed material was packed in a column with a bed height of 300mm. 5 L of hexane was passed through the fenugreek layer and the eluate (or effluent) collected from the bottom was recirculated through the fenugreek layer at 35 °C for a period of 10 h. After 10 h, the fenugreek layer was drained free of hexane. A solvent mixture (8 L) comprising isopropanol and water in a 4:1 ratio was passed through the layer by recirculating the eluent over a period of 8 h at 35 °C. After 8 h, the fenugreek bed was drained free of extract and all extract was collected. The collected extracts were concentrated in vacuo at 50 °C to a semi-solid mass. The concentrated pellet was redissolved in 5 L of deionized water to obtain a clear solution. The clear aqueous solution was slowly passed through a column containing 500 mL of strong acid cation exchange resin in macrop...

Embodiment 2

[0152] 1000 g of fenugreek seeds with a moisture content below 7% were crushed in a roller mill to a thickness of 5 mm. The crushed material was packed in a column with a bed height of 300 mm. 5 L of hexane was passed through the fenugreek layer and the eluate (or effluent) collected from the bottom was recirculated through the fenugreek layer at 35 °C for a period of 10 h. After 10 h, the fenugreek layer was drained free of hexane. A solvent mixture (8 L) comprising ethanol and water in a 4:1 ratio was passed through the layer by recirculating the eluent over a period of 8 h at 35 °C. After 8 h, the fenugreek bed was drained free of extract and all extract was collected. The collected extracts were concentrated in vacuo at 50°C to a semi-solid mass. The concentrated pellet was redissolved in 5 L of deionized water to obtain a clear solution. The clear aqueous solution was passed slowly over a period of 2 h through a column containing 500 mL of strong acid cation exchange ...

Embodiment 3

[0163] 1000 g of fenugreek seeds with a moisture content below 7% were crushed in a roller mill to a thickness of 6 mm. The crushed material was packed in a column with a bed height of 300mm. 5 L of hexane was passed through the fenugreek layer and the eluate (effluent) collected from the bottom was recirculated through the fenugreek layer at 35° C. for a period of 10 h. After 10 h, the fenugreek layer was drained free of hexane. A solvent mixture (8 L) comprising methanol and water in a 4:1 ratio was passed through this layer by recirculating the eluent over a period of 8 h at 35 °C. After 8 h, the fenugreek bed was drained free of extract and all extract was collected. The collected extracts were concentrated in vacuo at 50°C to a semi-solid mass. The concentrated pellet was redissolved in 5 L of deionized water to obtain a clear solution. The clear aqueous solution was passed slowly over a period of 2 h through a column containing 500 mL of strong acid cation exchange r...

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Abstract

The present invention relates to a novel botanical galactomannan, obtained from the plant Trigonella foenum graecum, as provided in structural formula I, optionally along with excipients for improving body composition and the factors related to the pre-diabetic and diabetic conditions, and a process of manufacture of the same. The present invention also relates to the use of the novel botanical galactomannan for improving body composition, reducing body fat, increasing muscle mass, enhancing strength and improving impaired glucose metabolism. The present invention also relates to the use of the novel botanical galactomannan for the improvement of factors related to the pre-diabetic and diabetic conditions.

Description

technical field [0001] The present invention relates to a novel plant-derived compound with the unique properties of improving body composition, increasing lean muscle mass, burning fat, increasing stamina, and improving glucose metabolism. [0002] The present invention also relates to the use of such compounds in subjects diagnosed with diabetes (subjects) and in subjects exhibiting a pre-diabetic condition. The present invention also relates to the use of such compounds for reducing body fat, increasing lean muscle mass and improving body composition. This improvement in body composition also improves glucose metabolism. The invention also relates to the use of such compounds in subjects with impaired glucose metabolism. The present invention also relates to the use of such compounds to increase muscle mass and enhance physical strength in a subject. [0003] The present invention also relates to methods of preparing such compounds for improving body composition, increas...

Claims

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Application Information

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IPC IPC(8): C07H1/08A61P3/10A61K36/48C07H3/06
CPCC07H3/06A61K31/48C07H1/08A61K31/702A61P3/04A61P3/08A61P43/00A61P9/00A61P3/10
Inventor 苏尼尔·布哈斯卡拉恩莫汉·维什瓦拉曼
Owner INDUS BIOTECH PVT
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