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Anti-herpesvirus infection medicinal composition

An anti-herpes virus and composition technology, applied in the directions of anti-viral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of inapplicable herpes simplex virus infection, application and clinical data of herpes simplex infection not mentioned, Toxic and side effects of topical steroid drugs and nucleoside drugs, to achieve reliable therapeutic effect, shorten recovery time, and inhibit the development of the disease course

Active Publication Date: 2011-05-11
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Among the external preparations of ibuprofen-pyridine-methanol already on the market in Japan, there is a product called Vesicum, which contains ibuprofen-pyridine-methanol as the main ingredient and a certain amount of n-docosanol as an auxiliary material, but the instructions for the preparation only indicate that Ibuprofen pyridine methanol can treat herpes zoster, but it does not mention any relevant application and clinical data for the treatment of herpes simplex infection, as well as any therapeutic activity data of n-docosanol, which means that this product in Japan is not applicable herpes simplex virus infection
[0014] To sum up, among the currently existing regimens for the treatment of herpes simplex virus infection, there are combinations of steroidal drugs and antiviral drugs, as well as combinations of n-docosanol and nucleoside drugs, but they also bring topical Toxic and side effects of steroidal drugs and nucleoside drugs

Method used

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  • Anti-herpesvirus infection medicinal composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 20

[0037] Embodiment 1 docosanol ibuprofen pyridine methanol cream

[0038] formula

[0039] Active ingredients: docosanol 100g, ibuprofen pyridinemethanol 50g

[0040] Other ingredients: liquid paraffin 20g, glyceryl monostearate 15g, Pingpingjiao 35g, methyl p-hydroxybenzoate 1g, propyl p-hydroxybenzoate 0.1g, glycerin 30g, water to 1000g.

[0041] Preparation method: heat, dissolve and clarify the prescription amount of docosanol, ibuprofen pyridine methanol, liquid paraffin, glyceryl monostearate, Pingpinga O, methyl p-hydroxybenzoate, and propyl p-hydroxybenzoate to obtain Oil phase, keep warm at about 80°C; mix glycerin and water and heat to about 80°C to obtain water phase; mix water and oil phase at about 80°C and quickly stir and emulsify for 10 minutes, then cool down to room temperature to obtain docosanol ibuprofen Pyridylmethanol cream.

Embodiment 2 20

[0042] Embodiment 2 docosanol butyl hydroxy acid cream

[0043] Active ingredients: 100 g of docosanol, 50 g of butadiene hydroxy acid, and the other ingredients and preparation method are the same as in Example 1.

Embodiment 3 20

[0044] Embodiment 3 docosanol hydrochloride doxepin cream

[0045] Active ingredients: 100 g of docosanol, 50 g of doxepin hydrochloride, and the other ingredients and preparation method are the same as in Example 1.

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PUM

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Abstract

The invention relates to a medicinal composition containing C21-C28 fatty alcohols and non-steroidal anti-inflammatory medicaments, which is applicable to the treatment of herpesvirus infection, particularly the recurrent simplex herpesvirus infection of skin or mucous membranes.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for resisting herpes virus infection, in particular to a pharmaceutical composition containing C21-C28 aliphatic alcohol and non-steroidal anti-inflammatory drugs. Background technique: [0002] Herpes virus infections are a serious and ongoing threat to public health, especially orofacial and genital herpes caused by the most common herpes simplex viruses (including types HSV-1 and HSV-2), and varicella-zoster virus (VZV ) infection caused by herpes zoster, etc., and a large number of animal herpes virus infections. [0003] After initial infection, HSV remains dormant in sensory nerve cells for the rest of the patient's life and can be reactivated under a variety of conditions, allowing the virus to travel across the nerves to the skin, where it then inflicts damage again, causing herpes pain , Recurrence of symptoms such as tingling. In case of recurrent infection, clinical symptoms will persi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P31/22
Inventor 虞忠郑晓东刘均胜张琼
Owner CHONGQING HUAPONT PHARMA
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