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Clathrate compound formed by Salvia miltiorrhiza Bunge and cyclodextrin and application thereof

A cyclodextrin and clathrate technology, which is applied in the field of inclusion complexes formed by Dan participating in cyclodextrin derivatives and their preparation

Inactive Publication Date: 2011-05-18
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: by using suitable cyclodextrin and / or cyclodextrin derivatives and / or mixtures thereof, to clathrate salvia miltiorrhiza, improve the physical properties of salvia miltiorrhiza almost insoluble in water, and realize the salvia miltiorrhiza The purpose of significantly improving the solubility in water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] At room temperature, treat 200 mg of Salvia miltiorrhiza in 20 ml of 40% hydroxypropyl-β-cyclodextrin for about 4 hours to obtain a slightly cloudy solution, which is filtered with a 0.2 μ microporous membrane until it becomes clear. The concentration of Salvia miltiorrhiza in the solution can be Up to 8-10mg / ml (the detection method is HPLC, and the detector is an evaporative light scattering detector). The solution was filled in ampoules, and the quality remained unchanged for 18 months after sterilization.

Embodiment 2

[0025] At room temperature, dissolve 30 g of hydroxypropyl-β-cyclodextrin in 80 ml of water, and treat 300 mg of Salvia miltiorrhiza for about 3 hours to obtain a slightly cloudy solution. Filter it with a 0.2 μ microporous membrane until it becomes clear, and take the clear solution Freeze-dry to obtain a white powder, which can be redissolved in water. It can be proved by differential scanning calorimetry that the white powder is in the form of clathrate, and the clathrate rate is 90%.

Embodiment 3

[0027] 8 mg of Salvia miltiorrhiza and 76 mg of β-cyclodextrin were fully ground in 50% ethanol 5 until a uniform paste was formed, and a white powder was obtained after vacuum drying.

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PUM

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Abstract

The invention relates to a clathrate compound formed by Salvia miltiorrhiza Bunge and cyclodextrin, and the clathrate compound is prepared from the following raw materials at weight ratio: 1 part of Salvia miltiorrhiza Bunge and 1-150 parts of cyclodextrin derivant; in water or ethanol medium containing water, the Salvia miltiorrhiza Bunge and one cyclodextrin derivant react; the obtained solvent is filtered by a microfiltration membrane until the solvent is clear; a clathrate compound is separated from the mixture; or the clathrate compound is prepared by high-energy grinding. The clathrate compound formed by the Salvia miltiorrhiza Bunge and the cyclodextrin has the advantae that the solubility of the Salvia miltiorrhiza Bunge in water is obviously improved, thus various liquid preparations required by medical treatment can be prepared so as to satisfy clinical requirements.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to an inclusion complex formed by dandelion participating in cyclodextrin derivatives, a preparation method and application thereof. Background technique [0002] Red ginseng is also known as red ginseng, mountain ginseng, purple danshen, red root, red warm medicine, purple ginseng Codonopsis , red ginseng, blood ginseng, blood ginseng root, blood salvia, red salvia , red salvia root, blood root, blood mountain root, wood goat milk, Lianma, mountain carrot, blood-activating root, backer red, shochu pot root, wild perilla root, mountain perilla root, Dahongpao, honey can, bee sugar jar, blossoming flowers Cicada root, Cicada root, Galloping horse root, Long sage root, Water sheepskin root. Salvia root mainly contains fat-soluble diterpenes and water-soluble phenolic acids, and also contains flavonoids, triterpenes, sterols and other components. Among the fat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K47/40A61P9/10A61P3/06A61P9/06A61P9/00A61P7/02A61P1/16A61P43/00A61P7/00A61P19/08A61P25/28A61P35/00A61P37/04A61P3/10A61P31/06A61P31/04A61K125/00
Inventor 宋德成高永清宁德科郎琳王磊
Owner TIANJIN PACIFIC PHARMA