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Process for the purification of fluromethyl 1,1,1,3,3,3,-hexafluoroisopropyl ether (sevoflurane)

A technology of hexafluoroisopropyl ether and hexafluoroisopropanol, which is applied in the field of fluoromethyl 1, can solve the problems of increasing the cost and complexity of the process method

Inactive Publication Date: 2011-05-18
HALOCARBON PROD CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that distillation adds cost and complexity to the process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Crude sevoflurane was previously prepared from HFIP, HF and formaldehyde (trioxane) by the reactive distillation process described in US Patent No. 6,469,219 and cooled until two layers formed. The organic layer mainly containing sevoflurane was separated. The crude sevoflurane product was then washed 8 times with water at room temperature and atmospheric pressure. After the final rinse, the sevoflurane layer contained less than 10 ppm of HFIP.

Embodiment 2

[0045] Crude sevoflurane was previously prepared from HFIP, HF and formaldehyde (trioxane) by the reactive distillation process described in US Patent No. 6,469,219 and cooled until two layers formed. The organic layer mainly containing sevoflurane was separated. Then, the crude sevoflurane product was washed with 50 wt% water four times at room temperature and atmospheric pressure, each time for about 30 min. After the final rinse, the sevoflurane layer contained less than 10 ppm of HFIP.

Embodiment 3

[0047] In the continuous flushing process, sevoflurane is previously prepared from HFIP, HF and formaldehyde equivalents by the reactive distillation process described in US Patent No. 6,469,219, cooled until two layers are formed. The organic layer containing primarily sevoflurane was separated and gravity flowed down a 1 inch diameter by 5 foot high column. The columns are packed with plastic packing to promote turbulent flow. Simultaneously, the water flows upwards through the column in countercurrent. The flow rate of crude sevoflurane was 0.5 kg / hr and the flow rate of water was 1.0 kg / hr. The purified sevoflurane left at the bottom of the tube contained less than 10 ppm of HFIP.

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PUM

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Abstract

A process for purifying crude fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane). The crude sevoflurane is repeatedly washed with water under conditions and for a time sufficient to reduce the level of 1,1, 1,3,3, 3-hexafluoroisopropanol (HFIP) to no more than 200 ppm or no more than 100 ppm.

Description

technical field [0001] The present invention relates generally to the production and purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) for use as an inhalational anesthetic. Background technique [0002] Several methods are known for the production of sevoflurane, notably using formaldehyde (or formaldehyde equivalents such as paraformaldehyde or trioxane), hydrogen fluoride (HF) and 1,1,1,3,3,3-hexafluoro Reaction of isopropanol (HFIP). US Patent No. 4,250,334 describes a process in which HFIP is added to a mixture of a stoichiometric excess of paraformaldehyde and HF with sufficient sulfuric acid to sequester most of the water formed in the reaction. WO 97 / 25303 describes a process for the production of sevoflurane in which substantially pure bis(fluoromethyl)ether (BFME) can be reacted with HFIP and sulfuric acid. US Patent No. 6,469,219 ('219) describes a process in which HFIP and formaldehyde equivalents can be reacted with excess HF und...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/38
CPCC07C41/01C07C41/38Y02P20/10C07C43/123C07C43/12
Inventor 巴里·琼斯乔尔·斯温森保罗·马泽尔
Owner HALOCARBON PROD CORP
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