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Drug composition for treating cardio-cerebrovascular diseases and preparation method

A technology for cardiovascular and cerebrovascular diseases and compositions, which can be applied to cardiovascular system diseases, drug combinations, and pharmaceutical formulations, etc. It can solve the problems affecting the full use of the beneficial effects of drugs and the waste of medicinal raw materials, so as to improve the utilization rate and improve the curative effect , the effect of reducing waste

Inactive Publication Date: 2011-05-25
四川小叶本草生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Tests have shown that there are still some shortcomings in the composition of the above-mentioned drugs, which not only affects the full play of the beneficial effects of the drugs, but also leads to the waste of medicinal raw materials

Method used

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  • Drug composition for treating cardio-cerebrovascular diseases and preparation method
  • Drug composition for treating cardio-cerebrovascular diseases and preparation method
  • Drug composition for treating cardio-cerebrovascular diseases and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 60 g of salvianolic acid B, 2 g of ferulic acid, 50 g of puerarin, 4 g of tanshinone IIA, 10 g of ligustilide and appropriate amount of pharmaceutical excipients were weighed as raw materials. After adding salvianolic acid B, ferulic acid and puerarin into medicinal PEG400 to dissolve, add tanshinone IIA, ligustilide and medicinal excipients, mix well, and set aside. Take medicinal gelatin, glycerin and water according to a volume ratio of 3:1.2:3, and after making capsule materials, press the above-mentioned standby medicinal liquid and capsule materials on a soft capsule press to make soft capsules, each weighing 0.5g, which is the basis Invented capsule medicine.

Embodiment 2

[0045] Micronize the same salvianolic acid B 20g, tanshinone II A 1g, ferulic acid 5g, and puerarin 20g, respectively, into the PEG-6000 melt, then add 20g of ligustilide, stir and mix well, and drip Make 1000 drop pills in the pill machine, be the drop pill medicine of the present invention.

Embodiment 3

[0047] Weigh the same salvianolic acid B 100g, ferulic acid 1g, puerarin 100g, tanshinone IIA 5g and ligustilide 4g respectively, add appropriate amount of medicinal excipients, press the conventional method to make 1000 tablets, and coat with film , is the tablet medicine of the present invention.

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Abstract

The invention provides a drug composition for treating cardio-cerebrovascular diseases and a preparation method. The drug composition is jointly formed by such active ingredients as 2-10 parts by weight of salvianolic acid B, 0.1-0.5 part by weight of tanshinone IIA, 0.1-0.5 part by weight of ferulic acid, 0.4-2 parts by weight of ligustilide and 2-10 parts by weight of puerarin and the auxiliary added ingredients acceptable in the drugs. Tests show that the drug composition can obviously reduce brain tissue hemorrhagic necrosis caused by brain ischemia reperfusion injury and alleviate injuries of nerve cells and nerve fibers.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition composed of active ingredients of natural medicines, and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a common and frequently-occurring disease, especially in the middle-aged and elderly people, which seriously endangers the health and quality of life of the middle-aged and elderly people. Traditional single Chinese medicine and its compound medicine have good preventive and therapeutic effects on cardiovascular and cerebrovascular diseases. For example, Danshen has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and stimulating menstruation, clearing heart and eliminating troubles, and is often used for the prevention of cardiovascular and cerebrovascular diseases. and treatment, its water-soluble ...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/365A61K31/352A61K31/343A61K31/192A61P9/00A61P9/10A61K36/537
Inventor 易进海刘云华陈燕刘玉红黄志芳刘倩伶
Owner 四川小叶本草生物科技有限公司
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