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A novel anti-aging skincare cream, the cosmetic device and cream within

An L-type and D-type technology, applied in skin care preparations, medical preparations containing active ingredients, radiation therapy, etc., can solve problems such as unexplained skin

Inactive Publication Date: 2011-05-25
YOLARE DERMACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies have been done on the feedback regulation of collagen levels, nor have they explained the temporary relief of signs of skin aging through existing methods

Method used

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  • A novel anti-aging skincare cream, the cosmetic device and cream within
  • A novel anti-aging skincare cream, the cosmetic device and cream within
  • A novel anti-aging skincare cream, the cosmetic device and cream within

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Manufacturing method of PLA

[0062] PLA peptides can be prepared from three individual amino acids by chemical synthesis and end-group modification. One of the compositing paths can be:

[0063] Step 1: CBZ-Cl+H-Pro-OH→Z-Pro

[0064] Step 2: Boc-D-Leu+D-Ala-OMe.HCL→Boc-D-Leu-D-Ala-OMe

[0065] Step 3: Boc-D-Leu-D-Ala-OMe→D-Leu-D-Ala-OMe+Z-Pro

[0066] Step 4: D-Leu-D-Ala-OMe+Z-Pro → Z-Pro-D-Leu-D-Ala-OMe

[0067] Step 5: Z-Pro-D-Leu-D-Ala-OMe → Z-Pro-D-Leu-D-Ala

[0068] Step 6: Z-Pro-D-Leu-D-Ala → Z-Pro-D-Leu-D-Ala-NHOH.

[0069] All reagents are of commercially available analytical grade. The purity of the final purified peptide was greater than 98% as shown by HPLC. Quality control analysis is shown in Figure 10 middle.

Embodiment 2

[0071] An example of a face cream formulation with PLA as an active ingredient:

[0072]

[0073]

Embodiment 3

[0075] Quantitative experiment of skin cells using LED goggles and PLA peptide

[0076] Dermal fibroblasts (ATCC No.: CRL-1762). Culture conditions are 37 °C, 5% CO 2 . All procedures are performed in sterile hoods. When the skin cells grew to 50-60% of the culture dish (10 cm in diameter), the culture solution was aspirated, the skin cells were washed with 5 mL of phosphate buffered saline (PBS), and then the PBS was aspirated. Then add 10 mL of PBS to the skin cells in the same Petri dish. The upper part of the skin cells is covered with a custom-made LED disc of the present invention, and the cells are illuminated with LED light programmed to have a specific wavelength, frequency and intensity. Turn off the LED light after a specified time. After turning off the LED light, replace the PBS solution in the Petri dish with 10 mL DNEM culture solution. In this culture medium, add the final concentration (final solution) to be 1×10 -5 M's specific collagenase inhibitors ...

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Abstract

This invention reveals a novel skin-rejuvenating method that combines the application of light physics (a Light emitting diode (LED) device with specific wavelength, intensity, and pulsing frequency) and biochemistry (a specific collagenase inhibitor). The programmed LED light can penetrate skin epidermis and activate the fibroblasts in dermis to produce new collagen. Meanwhile, the overproduction of collagen leads to the feedback activation of collagenase, which degrades collagen and eliminates the beneficiary effects of LED light. Hence, this invention also includes a topical cream containing a certain lipophilic collagenase inhibitor, which, when used alone or in combination with the light device, can maintain high levels of skin collagen, and eventually achieve the long term effects of reducing wrinkles, enhancing skin elasticity, and diminishing eye bags and dark circles. The light device and active-containing cream have achieved positive effects when tested in human trials.

Description

technical field [0001] The present invention relates to a novel anti-aging skin cream, a skin care device and the combination of a skin care device and a skin cream to stimulate collagen synthesis. More specifically, the present invention relates to a method of stimulating collagen synthesis using programmed LED light in combination with PLA peptides. Background technique [0002] Most of the visible signs of aging show up on the skin. Aging skin appears wrinkled, lacks elasticity, and loses radiance. At the biological core of skin aging is the gradual decrease in the level of collagen synthesized in the skin over time. The younger you are, the more collagen your skin produces; the older you get, the less collagen your skin retains. Therefore, there is a need to develop methods that can maintain high levels of collagen in the skin to rejuvenate the skin. [0003] Collagen in the skin is dynamically regulated (eg figure 1 shown). First, collagen is regulated to producti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/097C07K5/083A61K8/64A61Q19/08A61N5/06
CPCA61K8/64A61N2005/0652C07K5/0823A61K38/06A61N2005/0647A61N5/0616C07K5/06043A61N2005/0662A61K2800/782A61Q19/08
Inventor 黄岚仓勇瑞那托・琼斯
Owner YOLARE DERMACEUTICALS
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