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A quality control method, Xuefu Zhuyu technology, which is applied in the field of Chinese patent medicines, can solve the problems of not fully reflecting the uniformity and stability of product quality, difficulty in controlling the quality of Xuefu Zhuyu capsules, and large limitations
Active Publication Date: 2011-06-15
TIANJIN HONGRENTANG PHARM CO LTD
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For the compound Xuefu Zhuyu Capsules composed of eleven medicinal materials, only the qualitative identification of one medicinal material and the content determination of a single index component are used...
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example 1
[0029] Example 1: Take 100g of Chinese medicinal materials peach kernel, 150g of angelica, 100g of red peony root, 100g of citrus aurantii (stir-fried with bran), 75g of Chuanxiong, and 50g of Bupleurum. Add 150g of Achyranthes bidentata, 150g of Rehmannia glutinosa, 75g of bellflower, 50g of licorice and other five flavors and 100g of peach kernel to decoct three times, filter, combine the filtrate, concentrate it into a thick paste with a relative density of 1.15-1.25 (65-70°C), mix it with the above powder Homogenize, make granule, dry, pulverize, sieve, make 1000 capsules, obtain final product; The quality control method of this medicine comprises the following steps:
[0030] (1) Simultaneous determination of amygdalin (C 20 h 27 NO 11 ), paeoniflorin (C 23 h 28 o 11 ), naringin (C 27 h 32 o 14 ) content:
[0031] a. Chromatographic conditions: use octadecylsilane bonded silica gel as filler; acetonitrile-1% glacial acetic acid solution is mobile phase gradient elu...
example 2
[0043] Example 2: Take 100g of peach kernels, 150g of angelica, 100g of red peony root, 100g of citrus aurantii (stir-fried with bran), 75g of Chuanxiong, and 50g of Bupleurum chinensis. Add 150g of Achyranthes bidentata, 150g of Rehmannia glutinosa, 75g of bellflower, 50g of licorice and other five flavors and 100g of peach kernel to decoct three times, filter, combine the filtrate, concentrate it into a thick paste with a relative density of 1.15-1.25 (65-70°C), mix it with the above powder Homogenize, make granule, dry, pulverize, sieve, make 1000 capsules, obtain final product; The quality control method of this medicine comprises the following steps:
[0044] (1) Simultaneous determination of amygdalin (C 20 h 27 NO 11 ), paeoniflorin (C 23 h 28 o 11 ), naringin (C 27 h 32 o 14 ) content:
[0045] a. Chromatographic conditions: use octadecylsilane bonded silica gel as filler; acetonitrile-0.8% glacial acetic acid solution is mobile phase gradient elution (gradien...
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Abstract
The invention belongs to the technical field of Chinese patent medicines, and relates to a quality control method for a Xuefuzhuyu capsule prepared from traditional Chinese medicinal materials. In the quality control method, Chinese thorowax root and licorice root are utilized as comparison medicinal materials, and whether the formula of the Xuefuzhuyu capsule contains Chinese thorowax root and licorice root components is identified by means of thin-layer chromatography; and amygdalin (c20h27no11), paeoniflorin (c23h28o11) and naringin (c27h32o14) are used as comparison products, and the contents of the amygdalin, paeoniflorin and naringin in the formula of the Xuefuzhuyu capsule are determined by means of high performance liquid chromatography. By utilizing the quality control method provided by the invention, the situation in the original standards that the quality of compound prescription is controlled by controlling the content of a single indicator component is changed, and the controllability of the quality standards of the Xuefuzhuyu capsule is improved, so as to further ensure the inherent quality and curative effect of products; and the revised quality standards are improved, and the quality control of the Xuefuzhuyu capsule is improved.
Description
technical field [0001] The invention belongs to the technical field of Chinese patent medicines, and relates to a quality control method for Xuefu Zhuyu capsules made from Chinese medicinal materials. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, which is a preparation recorded in Volume 5 of the "Drug Standards of the Ministry of Health", and the standard WS 3 -B-0928-91 records the prescription and quality standard: [0003] 200g peach kernel (stir-fried), 150g angelica, 100g aurantium husk (stir-fried bran), 75g Chuanxiong, 50g Bupleurum, 150g safflower, 150g Achyranthes bidentata, 100g red peony root, 150g rehmannia glutinosa, 75g platycodon grandiflorum, 50g licorice [0004] Preparation method: above eleven flavors, grind 100g of peach kernels, angelica, red peony root, citrus aurantium, Chuanxiong, and Bupleurum into fine powder, sieve, mix well, add 100g of other five flavors such as safflower and peach kernels to decoct thr...
Claims
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