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Glycerol monooleate chitosan liquid crystal polymer

A technology of glycerol monooleate and liquid crystal polymer, which is applied in the directions of liquid crystal materials, chemical instruments and methods, medical preparations of inactive ingredients, etc.

Inactive Publication Date: 2011-06-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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This new type of polymer has no articles or patent reports

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  • Glycerol monooleate chitosan liquid crystal polymer
  • Glycerol monooleate chitosan liquid crystal polymer
  • Glycerol monooleate chitosan liquid crystal polymer

Examples

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Embodiment 1

[0049]Weigh 2 g of GMO and freshly prepared Sarrite reagent, dissolve them in appropriate amount of dichloromethane, stir to dissolve the two completely, slowly add the solution dissolved in Sarrite reagent into the GMO solution, and keep stirring, Make it react at room temperature for about 2 hours, completely oxidize the primary alcohol on the GMO to aldehyde, volatilize to remove dichloromethane, then filter the black viscous product through a Buchner funnel, wash the product with distilled water to remove excess saryl Special reagents to obtain aldehyde products with high purity, put the product in a vacuum drying oven for about 2 hours to fully dry it, and obtain dark green aldehyde products with high viscosity. Weigh chitosan 3.2g and disperse in glacial acetic acid solution, stir for about 6-7 hours, make it dissolve completely, dissolve the product obtained in the above steps, glacial acetic acid can be used as catalyst, and add molecular sieve as dehydrating agent, St...

Embodiment 2

[0051] Weigh 2 g of GMO and freshly prepared Sareite reagent, dissolve them in an appropriate amount of dichloromethane, stir to dissolve the two completely, slowly add the solution dissolved in Saruite reagent into the GMO solution, and keep stirring, Make it react at room temperature for about 2 hours, completely oxidize the primary alcohol on the GMO to aldehyde, volatilize and remove the dichloromethane, then filter the black viscous product on a Buchner funnel, and wash the product with distilled water to obtain Remove excess Charrite reagent, put the product in a vacuum drying oven for about 2 hours, make it fully dry, and obtain a dark green viscous aldehyde product. Weigh chitosan 2g and disperse it in anhydrous acetic acid, stir for about 6-7 hours to make it completely dissolved, dissolve the product obtained in the above steps, acetic acid can be used as a catalyst, and add molecular sieves as a dehydrating agent, at room temperature Stirring and reacting for 20-25 ...

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Abstract

The invention belongs to the field of medicinal high polymer materials and in particular relates to a chemical synthesis pathway. Glycerol monooleate (GMO) is grafted on a chitosan (2-position amino) to form a glycerol monooleate chitosan liquid crystal polymer. The glycerol monooleate chitosan liquid crystal polymer can serve as a carrier of a liquid crystal medicament delivery system. The GMO chitosan polymer is characterized in that the GMO molecule is grafted on the 2-position amino of a chitosan framework. The GMO chitosan polymer has the structural characteristic that n in the structure is an integer which is more than zero.

Description

technical field [0001] The invention belongs to the field of pharmaceutical polymer materials, and specifically relates to grafting glycerol monooleate (GMO) on chitosan (2-position amino group) through chemical synthesis to form a novel GMO chitosan liquid crystal polymer , this polymer can be used as a carrier of liquid crystal drug delivery system. The GMO chitosan polymer of the present invention is characterized in that the 2 amino groups of the chitosan skeleton are grafted with GMO molecules, and its structural features are as follows: [0002] [0003] n in the structure is an integer greater than zero Background technique [0004] Glyceryl monooleate (Glycery monooleate, GMO) is a non-ionic surfactant with a long-chain structure of glyceryl and oleic acid groups, with an HLB value of 3.3. At room temperature, GMO is a white waxy semi-solid with a density of 0.942g / cm3. When heated to 35°C, it melts into a light yellow oily liquid with a boiling point of about 2...

Claims

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Application Information

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IPC IPC(8): C08B37/08C09K19/38A61K47/36
Inventor 张建军高缘张敏燕孙婉瑾
Owner CHINA PHARM UNIV
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