Use of rupatadine for preventing or treating pulmonary fibrosis
A technology for pulmonary fibrosis and uses, which is applied in the field of new uses of known drugs, can solve problems such as lack of treatment methods for pulmonary fibrosis, and achieve the effects of significant curative effect, less toxic and side effects, and safe use.
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Embodiment 1
[0038] Example 1 Preparation of an animal model of pulmonary fibrosis
[0039] 1. Main reagents and experimental animals
[0040] The bleomycin used in the experiment was purchased from Nippon Kayaku, lot number X81040.
[0041] The SPF grade C57BL / 6 mice (male, 6-8 weeks old, 16-18 g) used in the experiment were purchased from the Institute of Zoology, Chinese Academy of Medical Sciences.
[0042] 2. Preparation method
[0043] The model of pulmonary fibrosis induced by bleomycin is the most recognized model of pulmonary fibrosis in the field of scientific research today. Bleomycin is an effective chemotherapeutic agent for skin cancer, but its medicinal value is limited by its dose-dependent pulmonary toxicity, which often manifests as pulmonary fibrosis. After administration of bleomycin, the alveolar endothelium was first damaged, and then bleomycin penetrated the injured alveolar endothelium to cause damage to the alveolar epithelial cells. Bleomycin causes lung damag...
Embodiment 2
[0046] Example 2 The method for treating pulmonary fibrosis with rupatadine
[0047] 1. Main reagents and experimental animals
[0048] Rupatadine, produced by Zhejiang Cifu Pharmaceutical Co., Ltd., is the raw material drug of rupatadine fumarate, and the content of rupatadine is >99%.
[0049] Pirfenidone, a drug that has been approved globally for the treatment of pulmonary fibrosis, has a good effect. The manufacturer of pirfenidone is Changzhou Wujin Qianhuang Sanyou Chemical Co., Ltd., which is the raw material drug, and the content of pirfenidone is >99%.
[0050] 2. Method
[0051] The animal model prepared in Example 1 was administered in groups after 7 days of modeling, and the grouping and administration were as shown in Table 1:
[0052] Table 1. Animal models of pulmonary fibrosis administered in groups 7 days after modeling
[0053]
[0054] Among them, A: Sham operation group (Sham); B: Model group (Model); C: Rupatadine 0.75mg / kg group (Rupa 0.75)...
Embodiment 3
[0055] Embodiment 3 measures mouse death rate
[0056] Calculated from the day of modeling as the 0th day, the death of experimental animals in each group was counted and calculated every day. The survival rate of animals in a certain group without death was calculated as 100%, and the survival rate of all animals in a certain group was calculated as 0%. The result See figure 1 . From figure 1 It can be seen that compared with the operation group, the mice were significantly dead after administration of bleomycin. Compared with the model group, the rupatadine 0.75 mg / kg and rupatadine 6 mg / kg groups can significantly reduce the death of mice caused by bleomycin.
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