Micro plasminogen mutant with function of inhibiting platelet aggregation and preparation method and application thereof
A technology for platelet aggregation and plasminogen, which is applied in biochemical equipment and methods, medical preparations containing active ingredients, enzymes, etc., and can solve the problem of no anti-platelet aggregation.
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[0027] The present invention will be described in further detail below in conjunction with the accompanying drawings.
[0028] For the tiny plasminogen mutant of the present invention, the polypeptide coding sequence containing the KGD sequence is fused to the tiny plasminogen gene when synthesizing the tiny plasminogen mutant gene.
[0029] According to the structural characteristics and mode of action of microplasminogen, a bifunctional mutant molecule of microplasminogen capable of dissolving thrombus and inhibiting platelet aggregation is designed, and produced by genetic engineering. The obtained product not only has efficient and specific thrombolytic function In addition, it also has new properties of anti-platelet aggregation, and the preparation process is simple and safe.
[0030] From the perspective of the three-dimensional structure of tiny plasminogen, the 7-10 amino acids are located outside the molecular structure, presenting a prominent Loop shape, away from t...
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