Graphene-based nano-pore monomolecular sensor and medium identification method thereof

A nanopore and graphene technology, which is applied in the field of nanofluid detection, can solve the problems affecting the resolution of the sensor, and achieve the effects of high structural stability, good toughness and strength

Inactive Publication Date: 2011-08-31
SOUTHEAST UNIV
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Problems solved by technology

However, the current current detection method is to apply a voltage at t

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  • Graphene-based nano-pore monomolecular sensor and medium identification method thereof
  • Graphene-based nano-pore monomolecular sensor and medium identification method thereof
  • Graphene-based nano-pore monomolecular sensor and medium identification method thereof

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[0014] In order to make the content of the present invention more obvious and understandable, further description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0015] Combine figure 1 , figure 2 As shown, the graphene-based nanopore monomolecular sensor of the present invention is a sandwich-like structure, and the radial electrode 2 is a single layer or multiple layers of graphene, sandwiched in the middle of the insulating layer 1, and the center of the sensor insulating layer is used A nanopore channel 8 is prepared by FIB. The graphene radial electrode 2 includes an anode and a cathode, which are respectively located at the two radial ends of the nanopore channel 8. The radial ammeter 7 is connected in series to the anode and cathode of the graphene radial electrode 2. Between; two Pt electrodes 5 are placed in the axial direction of the nanopore channel 8, respectively the anode and the cathode, and the axial ammeter 3 is conn...

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Abstract

The invention discloses a graphene-based nano-pore monomolecular sensor and a medium identification method thereof. In the graphene-based nano-pore monomolecular sensor, conductive single-layer or multi-layer graphene is used as a radial electrode; the graphene electrode is clamped inside an insulation layer, so the structural strength is enhanced; a nano-pore channel is formed on the insulation layer; the cathode and the anode of the radial electrode are located at both ends of the nano-pore channel in the radial direction respectively; and an axial electrode is arranged along the axial direction of the nano-pore channel. During medium identification, both ends of the nano pore are connected with a fluid pool unit, and voltage is exerted between the axial electrode and the radial electrode respectively; and when a medium passes through the nano pore, the medium in the channel is identified by measuring weak change of axial and radial current. The sensor has a simple structure; meanwhile, by comprehensive analysis of the radial current and the axial current, higher sensitivity and identification rate can be obtained; moreover, due to analysis, the pore-passing medium can be detected and the pore-passing state is analyzed according to the tested medium; therefore, the property of the medium can be analyzed.

Description

technical field [0001] The invention relates to the technical field of nanofluid detection, in particular to a graphene-based nanopore single-molecule sensor and a method for using the sensor to identify a medium to be measured. Background technique [0002] Biomolecular sensors using nanochannel technology can not only perform DNA sequencing, but also detect bacteria, protein molecules, and detect antigen-antibody reactions, thus having broad application prospects for disease detection and drug screening. [0003] When biomolecules pass through the nanopore channel, the ion current in the nanochannel will change. This is due to the different charges and structures on the surface of the biomolecules, resulting in different changes in the ion current generated when the molecule passes through the hole, so it is unique. Different biomolecules can thus be identified. This is the principle of current existing nanopore technology. [0004] The principle of the nanopore sensor i...

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Application Information

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IPC IPC(8): G01N27/49
Inventor 陈云飞沙菁倪中华张磊易红
Owner SOUTHEAST UNIV
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