Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing 2-chloropropionyl chloride with high optical activity

An optically active, chloropropionyl chloride technology is applied in chemical instruments and methods, preparation of carboxylate salts, and preparation of organic compounds. It can solve the problems of time-consuming and labor-intensive production, long production process, and high production cost. It achieves simple process, The effect of low production cost and short production time

Inactive Publication Date: 2011-09-21
NANTONG CHENGXIN AMINO ACID
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The present invention relates to a new method for preparing optically active 2-chloropropionyl chloride. Chinese Patent No. 200510094884 discloses a method for producing L-2-chloropropionyl chloride. In this patent, L-lactic acid is used as raw material and acyl The 2-chloropropionate is generated by the oxidizing agent, the 2-chloropropionic acid is obtained by hydrolysis, and finally the 2-chloropropionyl chloride is obtained by acylation with the acylating agent. The disadvantage of this method is that the production process is long and the process is complicated. The production cost is high, and the production is labor-intensive and time-consuming

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] In the best embodiment of the present invention, a method for preparing optically active 2-chloropropionyl chloride, firstly, the corresponding chemically active lactic acid and acylating agent are subjected to a chlorination reaction under a catalyst and an elevated temperature to generate a chemically active 2-chloropropionyl chloride and a small amount of high polymer, and then the optically active 2-chloropropionyl chloride was separated from the reaction compound.

[0017] Among them, to prepare optically active 2-chloropropionyl chloride, the catalyst adopts a basic catalyst, preferably pyridine, triethylamine, DMF, DMSO; more preferably pyridine.

[0018] The feeding method required for the reaction is dropwise addition at low temperature, preferably lactic acid is added dropwise to the acylating agent, the dropping temperature can be selected from -20 °C to 30 °C, preferably 0 to 5 °C, and the acylating agent can be selected from PCL 3 , SOCL 2 , preferably SOC...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for preparing optically active 2-chloropropionyl chloride, which comprises the following steps: firstly, using optically active lactic acid and acylating agent to generate optically active 2-chloropropionyl chloride and high polymer under the action of a catalyst; and secondly, separating the 2-chloropropionyl chloride and high polymer to obtain the optically active 2-chloropropionyl chloride. Compared with the prior art, the method has the advantages of short production flow, simple process, low production cost and short production time.

Description

Technical field [0001] The present invention relates to a method for preparing highly optically active 2-chloropropionyl chloride, in particular to a method for preparing highly optically active 2-chloropropionyl chloride used for plant protection agents and pharmaceutical intermediates. Background technique [0002] The present invention relates to a new method for preparing optically active 2-chloropropionyl chloride. Chinese Patent No. 200510094884 discloses a method for producing L-2-chloropropionyl chloride. In this patent, L-lactic acid is used as raw material and acyl The acylating agent generates 2-chloropropionate, which is hydrolyzed to obtain 2-chloropropionic acid. Finally, acylation with the acylating agent produces 2-chloropropionyl chloride. The disadvantages of this method are that the production process is long and the process is complex. The production cost is very high, and production is labor-intensive and time-consuming. Contents of the invention [0...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C53/50C07C51/60
Inventor 邢将军张新荣刘加根顾放
Owner NANTONG CHENGXIN AMINO ACID
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com