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Compound oral solution for treating infantile cough and preparation method thereof

A technology for children's cough and oral liquid, applied in the field of medicine, can solve the problems of slow absorption of children's lung cough granules, low bioavailability, moisture absorption and deterioration, etc., and achieves the effects of convenient administration, high clarity and long shelf life

Active Publication Date: 2013-03-06
天圣制药集团重庆药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing granules for the treatment of lung cough in children have slow absorption, poor taste and low bioavailability due to the crude drug powder used as medicine. At the same time, they are prone to moisture absorption and deterioration after being placed for a long time

Method used

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  • Compound oral solution for treating infantile cough and preparation method thereof
  • Compound oral solution for treating infantile cough and preparation method thereof
  • Compound oral solution for treating infantile cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] A kind of preparation method of the compound oral liquid for the treatment of children's cough disease, carries out as follows:

[0113] Raw material composition: Ginseng 21, Poria 19.5, Atractylodes macrocephala 9, Tangerine peel 18.5, Gallinaceae 19, Rhubarb (wine-burned) 11.5, Turtle shell 18.5, Digupi 22, Adenophora 38, Zhilicorice 11.5, Artemisia annua 28, wheat Dong 38, Gui Zhi 9, Dried Ginger 9, Aconite (made) 7, Melaleuca 28, Coltsfoot Flower 19, Aster 21, Morus alba 24, Dannanxing 7, Astragalus 21, Lycium barbarum 19, by weight ratio.

[0114] 1. Extraction of active ingredients

[0115] a. Take the above amount of Atractylodes macrocephala, tangerine peel, dried ginger, and coltsfoot flower plus 10 times the total weight of the medicinal materials and place them in the volatile oil extractor, extract twice, heat and boil for 1 hour each time, extract the volatile oil, and collect the volatile oil in another device , the aqueous solution is collected in anothe...

Embodiment 2

[0126] A preparation method for a compound oral liquid for treating children with cough, comprising the steps of:

[0127] Raw material composition: Ginseng 21, Poria 19.5, Atractylodes macrocephala 9, Tangerine peel 18.5, Gallinaceae 19, Rhubarb (wine-burned) 11.5, Turtle shell 18.5, Digupi 22, Adenophora 38, Zhilicorice 11.5, Artemisia annua 28, wheat Dong 38, Gui Zhi 9, Dried Ginger 9, Aconite (made) 7, Melaleuca 28, Coltsfoot Flower 19, Aster 21, Morus alba 24, Dannanxing 7, Astragalus 21, Lycium barbarum 19, by weight ratio.

[0128] 1. Extraction of active ingredients

[0129] a. Take the above-mentioned amount of Atractylodes macrocephala, tangerine peel, dried ginger, and coltsfoot flower to extract volatile oil, collect the volatile oil in a separate device, and collect the aqueous solution in a separate device, and keep the medicinal residue after extraction.

[0130] b. Take the above amount of Poria cocos, gallinacea, rhubarb, digupi, northern ginseng, roasted lic...

Embodiment 3

[0139] A preparation method for the active ingredient of a compound oral liquid for treating cough in children, comprising the steps of:

[0140] Raw material composition: Ginseng 21, Poria 19.5, Atractylodes macrocephala 9, Tangerine peel 18.5, Gallinaceae 19, Rhubarb (wine-burned) 11.5, Turtle shell 18.5, Digupi 22, Adenophora 38, Zhilicorice 11.5, Artemisia annua 28, wheat Dong 38, Gui Zhi 9, Dried Ginger 9, Aconite (made) 7, Melaleuca 28, Coltsfoot Flower 19, Aster 21, Morus alba 24, Dannanxing 7, Astragalus 21, Lycium barbarum 19, by weight ratio.

[0141] 1. Extraction of active ingredients

[0142] a. Take the above-mentioned amount of ginseng, Atractylodes macrocephala, tangerine peel, dried ginger, rhubarb, coltsfoot, aconite, and dannanxing for reflux extraction at 80°C for 2 times. For the first time, add ethanol that is 10 times the weight of the total weight of the medicinal materials, and for the second time add Ethanol in an amount 8 times the total weight of m...

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PUM

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Abstract

The invention discloses a compound oral solution for treating infantile cough, which is prepared from the following raw materials in parts by weight through active ingredient extraction, purification and formation: 21 parts of ginseng, 19.5 parts of tuckahoe, 9 parts of bighead atractylodes rhizome, 18.5 parts of dried orange peel, 19 parts of gizzard pepsin, 11.5 parts of rhubarb roasted with wine, 18.5 parts of turtle shell, 22 parts of wolfberry bark, 38 parts of radix glehniae, 11.5 parts of roasted licorice, 28 parts of sweet wormwood, 38 parts of ophiopogon root, 9 parts of cassia twig, 9 parts of dried ginger, 7 parts of prepared monkshood, 28 parts of snakegourd fruit, 19 parts of coltsfoot flower, 21 parts of aster, 24 parts of mulberry bark, 7 parts of arisaema cum bile, 21 parts of milk vetch and 19 parts of medlar. The active ingredients in the compound oral solution disclosed by the invention disperse in the medium in a molecular or granular state, thus the compound oral solution has the advantages of large dispersion degree and high absorption rate and quickly exerts the treatment effect; and simultaneously, the compound oral solution is easy to realize the divided dose, is convenient to take, reduces the irritation of medicines, has better taste and is especially suitable for old people and children. The compound oral solution disclosed by the invention has the advantages of stable property, high clarity, long shelf life (2 years) and high bioavailability, and has good treatment effect and no toxic side effect when used for treating infantile cough.

Description

technical field [0001] The invention relates to a medicine for treating cough and a preparation method thereof, in particular to a compound oral liquid for treating cough in children and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Pediatric cough is one of the common diseases in pediatrics, which can occur all year round, especially in winter and spring. According to the medical cases in a pediatric hospital, the cases of cough in children rank first among the medical cases. [0003] Pediatric cough is a relatively stubborn disease among pediatric diseases. Children's cough disease is the deficiency of lung and spleen in children, phlegm and dampness, resulting in cough or thick yellow phlegm, cough, cough, sputum, shortness of breath, shortness of breath, cold and fever in children, namely pneumonia, bronchitis and other symptoms, long-term persistent lingering If it does not heal, it will turn into chronic cou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/9068A61K36/752A61K36/605A61K36/54A61K36/428A61K36/28A61K36/23A61K36/076A61K35/56A61K35/37A61P11/14A61K35/57
Inventor 刘行鹏刘群昝琼向洪
Owner 天圣制药集团重庆药物研究院有限公司
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