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Hydrogel forming covalent cross-linking rapidly under mild conditions and preparation method thereof

A hydrogel and general-type technology, applied in prosthesis, bandage, surgery, etc., can solve the problems of slow hydrogel, unsuitable for surgical sealant, and difficult to control the actual operation of the hydrogel system, achieving excellent viscoelasticity, The effect of structural stability

Active Publication Date: 2013-03-13
HAINAN JIANKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This FocalSeal as a surgical sealant ? The disadvantage of the hydrogel system is that it is somewhat difficult to control in practice
However, since the two solutions disclosed in WO2008 / 131325 are mixed to form a hydrogel slowly (about 3 minutes), it is not suitable as a surgical sealant

Method used

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  • Hydrogel forming covalent cross-linking rapidly under mild conditions and preparation method thereof
  • Hydrogel forming covalent cross-linking rapidly under mild conditions and preparation method thereof
  • Hydrogel forming covalent cross-linking rapidly under mild conditions and preparation method thereof

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preparation example Construction

[0044] The preparation method of above-mentioned hydrogel comprises the following steps:

[0045] 1) Dissolve components A and B in a solution with a pH of 7 to 8 to obtain a mixed solution of components A and B respectively;

[0046] 2) Mix the mixed solutions of components A and B to obtain a hydrogel.

[0047] Preferably, the mass volume concentration of the mixed solution of components A and B is 5%-20%.

[0048] Preferably, components A and B are mixed in a molar ratio of 4:1 to 1:4.

[0049] Preferably, the solution with a pH of 7-8 is a sodium phosphate buffer. Of course, other buffers can also be used.

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Abstract

The invention discloses a covalently cross-linked hydrogel rapidly formed under mild conditions and a preparation method thereof. The hydrogel includes two components of NHS ester of PEG and PEG containing N-terminal cysteine. The two components are dissolved and mixed to obtain a hydrogel. The hydrogel of the present invention can quickly form a covalently cross-linked hydrogel under mild conditions, and is particularly suitable for making a surgical sealant.

Description

technical field [0001] The invention relates to a hydrogel and a preparation method thereof, in particular to a hydrogel capable of rapidly forming covalent crosslinks under mild conditions and a preparation method thereof. Background technique [0002] Hydrogel (Hydrogel) is a hydrophilic polymer network structure, insoluble in water, but can absorb and retain a large amount of water, highly swellable in aqueous solution, and has good biocompatibility and similarity. They can be used in surgical sealants and adhesives, drug release, tissue repair and tissue engineering in the field of medicine and biology. [0003] Existing hydrogel systems are usually formed through chemical or physical actions. Chemical crosslinking to form aqueous gels often involves the use of toxic crosslinking agents and free radicals, and the resulting hydrogels are usually not biodegradable. On the other hand, physical hydrogels are formed through non-covalent interactions, such as hydrogen bonds,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L71/08C08J3/24C08J3/075C08G65/48C08G81/00A61L15/26A61L15/42A61L24/04
CPCC08G65/3356A61L27/18C08G65/33337C08G65/33341C08J3/075C08J3/246C08J2371/02C08L71/02
Inventor 胡碧煌胡晓阳胡天柱
Owner HAINAN JIANKE PHARMA