Method for realizing no-wound human blood glucose measuring by utilizing volume pulse wave characteristic value

A volume pulse wave and eigenvalue technology, applied in blood characterization devices, catheters, etc., can solve the problems of high accuracy requirements of detection equipment, influence measurement results, and low measurement accuracy, and achieve convenient modeling, simple detection equipment, and high accuracy. The effect of precision detection

Inactive Publication Date: 2011-10-19
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

The technical difficulties faced by this method are as follows: (1) The spectrum acquisition process is easily interfered by the background spectr

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  • Method for realizing no-wound human blood glucose measuring by utilizing volume pulse wave characteristic value
  • Method for realizing no-wound human blood glucose measuring by utilizing volume pulse wave characteristic value
  • Method for realizing no-wound human blood glucose measuring by utilizing volume pulse wave characteristic value

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specific Embodiment approach 1

[0014] Specific implementation mode 1. Combination figure 1 Describe this embodiment, a method for non-invasively measuring human blood sugar by using the characteristic value of the volume pulse wave, the method is realized by the following steps:

[0015] a: Perform an oral glucose tolerance test on the subject. During the 150 minutes of the test, the volume pulse wave is measured every 5 minutes, and the characteristic value is extracted. The characteristic value is represented by h 1 / h 2 、h 1 / h 3 Said, while utilizing the biochemical analyzer to record the corresponding real-time blood glucose value. Using multiple linear regression algorithm to establish volume pulse wave eigenvalue h 1 / h 2 、h 1 / h 3 and the linear correlation model between instant blood glucose values.

[0016] b: In actual application, measure the volume pulse wave of the subject, and bring the characteristic value of the volume pulse wave into the model established in step a, so as to obtain...

specific Embodiment approach 2

[0017] Specific embodiment two, combine figure 2 and Fig. 3 illustrate this embodiment, this embodiment is the embodiment described in Embodiment 1:

[0018] A. The subjects were subjected to a glucose tolerance test. Weigh 75g of glucose powder with an electronic balance, and take it with 250ml of warm boiled water. In the two and a half hours after taking glucose, a set of data was measured every 5 minutes, including the characteristic value of the volume pulse wave and the corresponding real-time blood sugar value. A total of 28 sets of valid data were obtained. The above 28 groups of data were analyzed by multiple linear regression method, and a linear correlation model was established with a correlation coefficient of 0.83 and a cross-check standard deviation of 15.8 mg / dl. have a good correlation.

[0019] B. Bring the measured pulse wave characteristic value of the subject into the model, and the standard deviation of the obtained result is 16.0mg / dl. It shows tha...

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Abstract

The invention relates to a method for realizing no-wound human blood glucose measuring by utilizing a volume pulse wave characteristic value, relating to a blood glucose concentration measuring method. The invention provides a method for detecting the human blood glucose content with low detection cost, simple detection equipment and high measuring accuracy. The method is realized by the following steps of: a, measuring the volume pulse wave characteristic value of a subject and an instant blood glucose value corresponding to the volume pulse wave characteristic value at a regular interval; and building a linear correlation model between the volume pulse wave characteristic value and the instant blood glucose value by adopting a multiple linear regression algorithm; and b, measuring the volume pulse wave characteristic value of the subject, and substituting the obtained volume pulse wave characteristic value into the model built in the step a to obtain the real-time blood glucose value of the subject. In the method provided by the invention, the model is convenient to build, the detection equipment is simple, and no-wound and low-cost detection on the human blood glucose content can be realized. Twenty-four-hour uninterrupted measuring on the blood glucose of a patient can be realized by utilizing the method provided by the invention, and economical burden of the patient can be reduced.

Description

technical field [0001] The invention relates to a method for measuring blood sugar concentration, in particular to a method for non-invasive detection of blood sugar concentration. Background technique [0002] At present, conventional blood sugar testing mainly uses biochemical analyzers. This method needs to extract human blood samples and use chemical reagents to analyze the content of blood sugar indicators, which is an invasive test. It increases suffering and economic burden to patients, and also easily causes the transmission of some blood and body fluid infectious diseases. Many patients are unwilling to measure blood sugar and other biochemical indicators of the human body multiple times, which leads to delays in the disease and affects treatment and control. Therefore, the non-invasive, low-cost, rapid and accurate detection of blood sugar and other human biochemical indicators has always been the goal pursued by medical scientists. [0003] At present, the volum...

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Application Information

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IPC IPC(8): A61B5/145A61B5/02
Inventor 丁海泉卢启鹏
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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