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Use of phytoecdysones in the preparation of a composition for acting on metabolic syndrome

A technology of phytoecdysone and ecdysone, which is applied in the direction of medical preparations containing active ingredients, drug combinations, metabolic diseases, etc., and can solve problems such as toxicity and insufficient efficacy of abdominal obesity

Active Publication Date: 2011-11-02
BIOPHYTIS +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most edible products currently on the market appear to be insufficiently effective in treating abdominal obesity and, in some cases, have also been shown to be toxic (Pittle et al., 2005)

Method used

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  • Use of phytoecdysones in the preparation of a composition for acting on metabolic syndrome
  • Use of phytoecdysones in the preparation of a composition for acting on metabolic syndrome
  • Use of phytoecdysones in the preparation of a composition for acting on metabolic syndrome

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Embodiment Construction

[0028]In the present invention, it is proposed to provide concentrated doses of pure phytoecdysone, or through concentrated plant extracts of phytoecdysone, in order to improve the health of overweight people, or to avoid overweight caused by the accumulation of abdominal or visceral fat. It is one of the main clinical markers of metabolic syndrome and a risk factor for the onset of cardiovascular disease and type 2 diabetes.

[0029] The limiting dose of phytoecdysone contained in the composition according to the invention, allowing to obtain a positive therapeutic effect on fat mass, in humans is 0.3 to 0.5 mg / kg, ie an average of 20 to 30 mg per day. This estimate is based on the detection of physiological responses in mice (C57Bl6 line mice) at a dose of 5 mg / kg. Considering that the mean half-life of phytoecdysone is longer in humans than in mice, this dose has been adjusted for pharmacological correspondence (Koolman, 1989).

[0030] According to the present invention, ...

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Abstract

In order to reduce the negative effects of metabolic syndrome on the mammalian organism, it is envisaged in the invention to use phytoecdysones, so as to decrease the fat mass in an individual, in particular an overweight individual. The phytoecdysones are advantageously incorporated into a food composition. According to the invention, the phytoecdysones can be derived from food plants, such as quinoa.

Description

technical field [0001] The present invention relates to the use of phytoecdysone, either pure or in the form of an extract, for the preparation of a composition for the prevention or treatment of metabolic syndrome in mammals. More specifically, the use according to the invention allows reducing fat mass and / or reducing its accumulation, especially in the waist and abdomen. The present invention also relates to plant extracts concentrated in phytoecdysones which can be used to prepare such compositions. The present invention can be advantageously used in the field of agricultural food processing, so that edible products are rich in phytoecdysone, thereby making functional food or rehabilitation food. The invention is also useful in the medical field, for example, phytoecdysones are used in pharmaceutical compositions. Background technique [0002] Being overweight is a very common physiological condition today, regardless of age group and culture. This physiological disor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61K36/06A61K36/185A61K31/575A23L1/29A23L1/30A61P3/04A23L11/20A23L33/00
CPCA23L1/293A23L1/3002A61K36/21Y10S514/909A61K31/575A61K31/56A23K1/165A23K20/168A23L33/30A23L33/105A61P3/04A61P3/06A23K20/184
Inventor 斯坦尼斯拉斯·韦耶勒内·拉丰
Owner BIOPHYTIS
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