Application of drugs by using inula britannica total flavone extract for reducing blood sugar

A technology of total flavonoids and extracts, applied in the field of prevention and treatment of hyperglycemia, total flavonoids extract from Inula inula

Inactive Publication Date: 2011-11-16
JILIN UNIV
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  • Abstract
  • Description
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Problems solved by technology

Or use inula inula as raw material, the extraction process includes: (1) extraction: add inula inula or crushed material into 10%-100% ethanol 3-30 times the weight, soak for 2-10 hours, percolate After 12-24 hours, extract at 50-90°C or reflux for 2-3 times, stand still, filter, and concentrate to obtain the extract; (2) Use an adsorption resin column for purification, first use 1-10 times the volume of the resin column washed with water, then washed with 5%-50% ethanol at a concentration of 0.5-10 times the volume of the resin column, eluted with 50%-90% ethanol at a concentration of 1-10 times the volume of the resin column, concentrated, and dried , to obtain flavonoid extracts; but so far, there has been no report on the treatment of hyperglycemia diseases by the total flavonoid extract of Inula inula

Method used

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  • Application of drugs by using inula britannica total flavone extract for reducing blood sugar
  • Application of drugs by using inula britannica total flavone extract for reducing blood sugar
  • Application of drugs by using inula britannica total flavone extract for reducing blood sugar

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experiment example

[0012] Experimental Example: The present invention will be further described below in conjunction with pharmacodynamic experiments.

[0013] (1) Effect of Inula inula total flavonoids extract on blood sugar in normal mice

[0014] 1 Experimental method

[0015] 40 mice were randomly divided into 4 groups. They were the normal control group, the high, medium and low dose groups (300, 200, 100 mg / kg) of the total flavonoids extract of Inula inula. The normal group was given the same volume of distilled water every day, and the three dosage groups of the treatment group were given corresponding doses of total flavonoids extracts of Inula inulata every day, administered by intragastric administration, once a day, for 2 consecutive weeks, before the last administration , fasted for 12 hours, and 1 hour after administration, blood was collected from the retro-orbital venous plexus, serum was separated, and blood glucose was measured.

[0016] 2 results

[0017] 2.1 See Table 1 f...

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Abstract

The invention relates to an application of drugs by using an inula britannica total flavone extract for reducing blood sugar, which belongs to the field of traditional Chinese medicine. The invention provides the application of the inula britannica total flavone extract in preparation of drugs for reducing blood sugar. The inula britannica total flavone extract is used for preparing the drugs for reducing blood sugar, and has substantial curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the use of total flavonoids extract from Inula inula in preventing and treating hyperglycemic diseases. Background technique [0002] Inula britannica L.var.chinensis Reg. is a plant of Compositae (Inula britannica L.var.chinensis Reg.). It tastes salty, warm and non-toxic. It is mainly produced in Henan, Jiangsu, Hebei, Zhejiang, Anhui, Heilongjiang, Jilin and Liaoning. , Qi down, soft and hard, the effect of running water. The total flavonoids extract of Inula inula has been reported by relevant literature. Or use inula inula as raw material, the extraction process includes: (1) extraction: add inula inula or crushed material into 10%-100% ethanol 3-30 times the weight, soak for 2-10 hours, percolate After 12-24 hours, extract at 50-90°C or reflux for 2-3 times, stand still, filter, and concentrate to obtain the extract; (2) Use an adsorption resin col...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P3/10
Inventor 洪铁杨振
Owner JILIN UNIV
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