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Application of compound traditional Chinese medicine in prevention and treatment of osteoporosis disease

A technology of osteoporosis and compound traditional Chinese medicine, which is applied in the field of medicine, can solve the problems of no osteoporosis, uncertain long-term curative effect, and many side effects, so as to increase the number of osteoblasts per unit, enhance the developmental function of sexual organs, The effect of improving bone structure

Active Publication Date: 2012-12-05
QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, sex hormones and fluoride are commonly used in the prevention and treatment of osteoporosis in modern medicine, which have the disadvantages of high price, many toxic and side effects, and uncertain long-term efficacy.
[0009] Chinese patent 200410051250.4 discloses a drug for treating hyperlipidemia, which is composed of Ligustrum lucidum, Atractylodes macrocephala, Eucommia ulmoides, Panax notoginseng, Daji, Salvia miltiorrhiza, Coptis chinensis, and bergamot. It has been clinically applied for more than 20 years It is used to treat hyperlipidemia, arteriosclerosis, bran diabetes, metabolic syndrome and other diseases. It has been clinically used for many years, but it has not been used for the prevention and / or treatment of osteoporosis-related diseases including primary, Reports of secondary osteoporosis, hyperlipidemia or glucolipid syndrome and / or drug-induced (eg, glucocorticoid)-induced osteoporosis

Method used

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  • Application of compound traditional Chinese medicine in prevention and treatment of osteoporosis disease
  • Application of compound traditional Chinese medicine in prevention and treatment of osteoporosis disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Experimental Study of VAOF in the Prevention and Treatment of Osteoporosis in Ovariectomized Rats

[0026] Decreased androgen is one of the important causes of osteoporosis in elderly men. In this study, the model of kidney deficiency and porosis reproduced by detestation of 8-month-old male rats was used to prevent and treat with different doses of VAOF, and to conduct a comparative study with the positive drug Tridin. The curative effect mechanism of porosis provides a scientific basis for the further development and research of VAOF.

[0027] 1. Materials

[0028] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 5, Sanqi 5, Eucommia 10 and Bergamot 10), batch number: 100502, The positive drug, Tridin, was provided by Italian Rotta Pharmaceuticals, batch number: 2010024. This drug is used for the treat...

example 2

[0050] Example 2 Prevention and treatment effect of VAOF on ovariectomized osteoporosis in rats

[0051] 1. Materials

[0052] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 5, Sanqi 5, Eucommia 10 and Bergamot 10), batch number: 100502, Positive drug oyster calcium carbonate tablets, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd., batch number: T90016; E 2 The detection kit was provided by Beijing Kemei Dongya Biotechnology Co., Ltd., batch number: 110325.

[0053] (2) Animals: 72 32-week-old, clean-grade, SD female rats with a body weight of (390±20g) were selected and fed with common feeds formulated by the Guangdong Provincial Experimental Branch Center, referring to AIN-93M rodents For animal feed formulations, replace ingredients derived from soybeans in the feed with appropriate substances to avoid interfer...

Embodiment 4

[0137] Example 4 : Effect of VAOF on hydrocortisone-induced osteoporosis in rats

[0138] Excessive use of cortisol drugs is one of the important causes of drug-induced osteoporosis. In this study, adult male rats were subcutaneously injected with hydrocortisone (36mg / kg) to reproduce the drug-induced osteoporosis model induced by excessive cortisol drugs, and different doses of VAOF were used for prevention and treatment. (Tridin) conducted a comparative study, aiming to explore the efficacy of Zhenzhu Tiaozhi Decoction in treating osteoporosis induced by excessive use of corticosteroids, and to provide a scientific basis for the further development and research of Zhenzhu Tiaozhi Decoction.

[0139] 1. Materials and methods

[0140] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 6, Sanqi 6, Eucommia 10 and Bergamot 10)...

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Abstract

The invention discloses application of a compound traditional Chinese medicine to prevention and treatment of an osteoporosis disease, belonging to new application of the traditional Chinese medicine. The compound traditional Chinese medicine is prepared from the following Chinese medicinal herbs in percentage by weight: 15-35 percent of glossy privet fruit, 10-25 percent of Japanese thistle herbor root, 5-20 percent of largehead atractylodes rhizome, 5-20 percent of root of red-rooted salvia, 5-15 percent of coptis root, 5-15 percent of pseudo-ginseng root, 5-15 percent of eucommia and 5-15percent of fingered citron. As proved by an experiment, the compound traditional Chinese medicine has remarkable treatment effects on the prevention and treatment of primary osteoporosis, secondary osteoporosis, osteoporosis caused by hyperlipidaemia or an osteoporosis disease caused by glucose metabolism syndrome, definite clinical curative effect and no remarkable side effect according to observation.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a compound traditional Chinese medicine containing Ligustrum lucidum in preventing and treating osteoporosis. Background technique [0002] Osteoporosis (osteoporosis) is common disease among the elderly, frequently-occurring disease, and its main symptoms and hazards are pain, shortened body length, hunchback, fracture in severe cases, and decreased respiratory function. [0003] Osteoporosis is a group of bone diseases caused by various reasons. Bone tissue has normal calcification, and the ratio of calcium salt to matrix is ​​normal. It is a metabolic bone lesion characterized by a decrease in the amount of bone tissue per unit volume. Pathological anatomy shows that the bone cortex is thin, the trabecular bone is sparse and atrophic, and the osteoid layer is not thick. It is a complex result of the interaction of factors such as genetics, hormones and nutrition. C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P19/10
Inventor 郭姣
Owner QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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